Trait

Paraproteinemia

An abnormal immunoglobulin or part of an Ig (light chain) in the circulation. Paraproteins are typically produced by a clonal population of B-cell derived plasma cells.

HPO HP:0031047

Also called: Monoclonal hypergammaglobulinemia
Body system: Abnormal cellular phenotype Abnormality of blood and blood-forming tissues Laboratory abnormality Abnormality of the immune system

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2 genes linked to Paraproteinemia

Changes in these genes cause rare conditions in which Paraproteinemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CCND1cyclin D1	Not recorded	In 1 condition
LIG4DNA ligase 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Monoclonal elevation of circulating IgM concentration1 gene

Broader traits

Increased antibody level in blood

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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