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Trait

Increased naive B cell proportion

The proportion of naive B cellsin the blood circulation is above the upper limit of normal with respect to the reference range for a given sex and age-group.

HPO HP:0030371

Summary

Also called
Increased proportion of naive B cells
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

2 genes linked to Increased naive B cell proportion

Changes in these genes cause rare conditions in which Increased naive B cell proportion is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
RC3H1ring finger and CCCH-type domains 1AlwaysIn 1 condition
IKZF2IKAROS family zinc finger 2Often (30–79%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal naive B cell proportion

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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