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Trait

Increased effector memory CD4+ T cell proportion

An abnormally increased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype.

HPO HP:0025625

Summary

Also called
Increased CD4+ effector memory T cell proportion, Increased effector memory CD4-positive T cell proportion, Increased proportion of CD4+ effector memory T cells, Increased proportion of CD4-positive effector memory T cells, Increased proportion of effector CD4-positive, alpha-beta T cells
Body system
Abnormality of blood and blood-forming tissuesAbnormality of the immune system

2 genes linked to Increased effector memory CD4+ T cell proportion

Changes in these genes cause rare conditions in which Increased effector memory CD4+ T cell proportion is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
ITPR3inositol 1,4,5-trisphosphate receptor type 3AlwaysIn 1 condition
IKZF2IKAROS family zinc finger 2Often (30–79%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal effector memory CD4+ T cell proportionIncreased memory CD4+ T cell proportion

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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