{
  "url": "https://dantelabs.com/traits/increased-effector-memory-cd4-t-cell-proportion",
  "trait": {
    "bundleId": "2026.10.18-8b139e39",
    "release": "2026-09-01",
    "slug": "increased-effector-memory-cd4-t-cell-proportion",
    "id": "HP:0025625",
    "name": "Increased effector memory CD4+ T cell proportion",
    "definition": "An abnormally increased proportion of effector memory CD4+ T cells compared to the total number of T cells in the blood. These are memory cells that are short-lived cells that migrate to the site of an infection and attempt to eliminate the pathogen. These cells may have a CD3/CD4/CD62L-/CD45RA phenotype.",
    "synonyms": [
      "Increased CD4+ effector memory T cell proportion",
      "Increased effector memory CD4-positive T cell proportion",
      "Increased proportion of CD4+ effector memory T cells",
      "Increased proportion of CD4-positive effector memory T cells",
      "Increased proportion of effector CD4-positive, alpha-beta T cells"
    ],
    "systems": [
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-effector-memory-cd4-t-cell-proportion",
        "name": "Abnormal effector memory CD4+ T cell proportion",
        "url": "https://dantelabs.com/traits/abnormal-effector-memory-cd4-t-cell-proportion"
      },
      {
        "slug": "increased-memory-cd4-t-cell-proportion",
        "name": "Increased memory CD4+ T cell proportion",
        "url": "https://dantelabs.com/traits/increased-memory-cd4-t-cell-proportion"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "itpr3",
        "symbol": "ITPR3",
        "hgnc": "HGNC:6182",
        "name": "inositol 1,4,5-trisphosphate receptor type 3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/itpr3"
      },
      {
        "slug": "ikzf2",
        "symbol": "IKZF2",
        "hgnc": "HGNC:13177",
        "name": "IKAROS family zinc finger 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ikzf2"
      }
    ]
  }
}