Trait

Hypovolemic shock

A state of shock characterized by decreased circulating blood volume in relation to total vascular capacity. This type of shock is characterized by a reduction of diastolic filling pressures.

HPO HP:0031274

Body system: Abnormality of the cardiovascular system

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5 genes linked to Hypovolemic shock

Changes in these genes cause rare conditions in which Hypovolemic shock is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
DSPdesmoplakin	Often (30–79%)	In 1 condition
JUPjunction plakoglobin	Often (30–79%)	In 1 condition
SCNN1Asodium channel epithelial 1 subunit alpha	Often (30–79%)	In 1 condition
SCNN1Bsodium channel epithelial 1 subunit beta	Often (30–79%)	In 1 condition
SCNN1Gsodium channel epithelial 1 subunit gamma	Often (30–79%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Shock

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

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