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Trait

Decreased plasma methionine

Clinical name: Hypomethioninemia

A decreased concentration of methionine in the blood.

HPO HP:0003658

Summary

Also called
Decreased serum methionine
Body system
Laboratory abnormality

3 condition reports read genes linked to this trait

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8 genes linked to Decreased plasma methionine

Changes in these genes cause rare conditions in which Decreased plasma methionine is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
MMADHCmetabolism of cobalamin associated DAlwaysIn 2 conditions
MTR5-methyltetrahydrofolate-homocysteine methyltransferaseAlwaysIn 1 condition
ABCD4ATP binding cassette subfamily D member 4Often (30–79%)In 1 condition
MMACHCmetabolism of cobalamin associated COften (30–79%)In 2 conditions
MTHFRmethylenetetrahydrofolate reductaseOften (30–79%)In 1 condition
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductaseOften (30–79%)In 2 conditions
PRDX1peroxiredoxin 1Often (30–79%)In 1 condition
LMBRD1LMBR1 domain containing 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal circulating methionine concentration

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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