{
  "url": "https://dantelabs.com/traits/hypomethioninemia",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "hypomethioninemia",
    "id": "HP:0003658",
    "name": "Decreased plasma methionine",
    "label": "Hypomethioninemia",
    "definition": "A decreased concentration of methionine in the blood.",
    "synonyms": [
      "Decreased serum methionine"
    ],
    "systems": [
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-circulating-methionine-concentration",
        "name": "Abnormal circulating methionine concentration",
        "url": "https://dantelabs.com/traits/abnormal-circulating-methionine-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "mmadhc",
        "symbol": "MMADHC",
        "hgnc": "HGNC:25221",
        "name": "metabolism of cobalamin associated D",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mmadhc"
      },
      {
        "slug": "mtr",
        "symbol": "MTR",
        "hgnc": "HGNC:7468",
        "name": "5-methyltetrahydrofolate-homocysteine methyltransferase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mtr"
      },
      {
        "slug": "abcd4",
        "symbol": "ABCD4",
        "hgnc": "HGNC:68",
        "name": "ATP binding cassette subfamily D member 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd4"
      },
      {
        "slug": "mmachc",
        "symbol": "MMACHC",
        "hgnc": "HGNC:24525",
        "name": "metabolism of cobalamin associated C",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mmachc"
      },
      {
        "slug": "mthfr",
        "symbol": "MTHFR",
        "hgnc": "HGNC:7436",
        "name": "methylenetetrahydrofolate reductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mthfr"
      },
      {
        "slug": "mtrr",
        "symbol": "MTRR",
        "hgnc": "HGNC:7473",
        "name": "5-methyltetrahydrofolate-homocysteine methyltransferase reductase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mtrr"
      },
      {
        "slug": "prdx1",
        "symbol": "PRDX1",
        "hgnc": "HGNC:9352",
        "name": "peroxiredoxin 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prdx1"
      },
      {
        "slug": "lmbrd1",
        "symbol": "LMBRD1",
        "hgnc": "HGNC:23038",
        "name": "LMBR1 domain containing 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbrd1"
      }
    ]
  }
}