Trait

Chronic absent circulating IgG4

A lasting absence of immunoglobulin G4 (IgG4) in the blood, whereby at most trace quantities of IgG4 can be measured.

Also called: Chronic (near) absent IgG4 in blood
Body system: Abnormal cellular phenotype Abnormality of blood and blood-forming tissues Laboratory abnormality Abnormality of the immune system

This page as data

Add .json to the page's address, or ask for application/json, to read it as JSON.

library(jsonlite)

url <- "https://dantelabs.com/traits/chronic-absent-circulating-igg4.json"
page <- fromJSON(url)
page$trait$name

Open the JSON

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1 gene linked to Chronic absent circulating IgG4

Changes in these genes cause rare conditions in which Chronic absent circulating IgG4 is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CR2complement C3d receptor 2	Always	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Decreased circulating IgG4 concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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