{
  "url": "https://dantelabs.com/traits/chronic-absent-circulating-igg4",
  "trait": {
    "bundleId": "2026.10.17-8666dff2",
    "release": "2026-09-01",
    "slug": "chronic-absent-circulating-igg4",
    "id": "HP:0041059",
    "name": "Chronic absent circulating IgG4",
    "definition": "A lasting absence of immunoglobulin G4 (IgG4) in the blood, whereby at most trace quantities of IgG4 can be measured.",
    "synonyms": [
      "Chronic (near) absent IgG4 in blood"
    ],
    "systems": [
      {
        "slug": "abnormal-cellular-phenotype",
        "name": "Abnormal cellular phenotype",
        "url": "https://dantelabs.com/traits/abnormal-cellular-phenotype"
      },
      {
        "slug": "abnormality-of-blood-and-blood-forming-tissues",
        "name": "Abnormality of blood and blood-forming tissues",
        "url": "https://dantelabs.com/traits/abnormality-of-blood-and-blood-forming-tissues"
      },
      {
        "slug": "abnormality-of-metabolism-homeostasis",
        "name": "Laboratory abnormality",
        "url": "https://dantelabs.com/traits/abnormality-of-metabolism-homeostasis"
      },
      {
        "slug": "abnormality-of-the-immune-system",
        "name": "Abnormality of the immune system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-immune-system"
      }
    ],
    "broader": [
      {
        "slug": "decreased-circulating-igg4-concentration",
        "name": "Decreased circulating IgG4 concentration",
        "url": "https://dantelabs.com/traits/decreased-circulating-igg4-concentration"
      }
    ],
    "narrower": [],
    "genes": [
      {
        "slug": "cr2",
        "symbol": "CR2",
        "hgnc": "HGNC:2336",
        "name": "complement C3d receptor 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cr2"
      }
    ]
  }
}