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Gene

POLE2

DNA polymerase epsilon 2, accessory subunit

Summary

Cytogenetic location
14q21.3
Coordinates
Chromosome 14: 49,643,555–49,688,214 (GRCh38)
Exons
19 exons across 44.7 kb
Protein
527 amino acids
Also known as
DPE2
MANE Select transcript
ENST00000216367.10NM_002692.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads POLE2 yet. The test sequences your whole genome, so your data includes it all the same.

How POLE2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 14, with a bracket where POLE2 sits. POLE2 and 11 genes near it on chromosome 14, from 49,165,885 to 50,165,884.Chromosome 1414q21.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3349.2 Mb49.4 Mb49.6 Mb49.8 Mb50 MbRPS29: 49,500,452–49,599,164, reverse strandLRR1: 49,598,480–49,614,673, forward strandLRR1RPL36AL: 49,600,815–49,620,649, reverse strandRPL36ALMGAT2: 49,620,799–49,633,312, forward strandMGAT2DNAAF2: 49,623,701–49,635,284, reverse strandDNAAF2POLE2: 49,643,555–49,688,214, reverse strandPOLE2KLHDC1: 49,693,100–49,753,636, forward strandKLHDC1KLHDC2: 49,767,540–49,828,902, forward strandKLHDC2NEMF: 49,780,955–49,853,055, reverse strandNEMFARF6: 49,892,608–49,897,202, forward strandARF6VCPKMT: 50,108,631–50,116,600, reverse strandVCPKMTSOS2: 50,116,801–50,231,930, reverse strandSOS2Diagram of POLE2: 19 exons on the reverse strand of chromosome 14Exon 19: 49,643,555–49,643,670, 116 basesExon 18: 49,647,293–49,647,360, 68 basesExon 17: 49,650,265–49,650,441, 177 basesExon 16: 49,651,269–49,651,377, 109 basesExon 15: 49,653,990–49,654,067, 78 basesExon 14: 49,654,155–49,654,214, 60 basesExon 13: 49,654,784–49,654,838, 55 basesExon 12: 49,655,005–49,655,094, 90 basesExon 11: 49,655,671–49,655,843, 173 basesExon 10: 49,663,315–49,663,387, 73 basesExon 9: 49,664,626–49,664,674, 49 basesExon 8: 49,665,107–49,665,163, 57 basesExon 7: 49,666,330–49,666,413, 84 basesExon 6: 49,669,524–49,669,598, 75 basesExon 5: 49,674,123–49,674,216, 94 basesExon 4: 49,674,350–49,674,427, 78 basesExon 3: 49,679,725–49,679,800, 76 basesExon 2: 49,683,593–49,683,693, 101 basesExon 1: 49,688,136–49,688,214, 79 bases191510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.7 kb of the gene's 44.7 kb; 1,584 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). POLE2 gene: DNA polymerase epsilon 2, accessory subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/pole2

Vancouver

Dante Labs. POLE2 gene: DNA polymerase epsilon 2, accessory subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pole2

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