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Gene

PLA2G7

phospholipase A2 group VII

Summary

Cytogenetic location
6p12.3
Coordinates
Chromosome 6: 46,704,201–46,735,375 (GRCh38)
Exons
12 exons across 31.2 kb
Protein
441 amino acids
Also known as
PAFAH, LDL-PLA2, Lp-PLA2
MANE Select transcript
ENST00000274793.12NM_005084.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PLA2G7 yet. The test sequences your whole genome, so your data includes it all the same.

How PLA2G7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where PLA2G7 sits. PLA2G7 and 8 genes near it on chromosome 6, from 46,219,788 to 47,219,787.Chromosome 66p12.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2746.4 Mb46.6 Mb46.8 Mb47 Mb47.2 MbRCAN2: 46,220,718–46,491,972, reverse strandRCAN2CYP39A1: 46,549,383–46,652,831, reverse strandCYP39A1SLC25A27: 46,652,915–46,678,190, forward strandSLC25A27TDRD6: 46,687,875–46,704,319, forward strandTDRD6PLA2G7: 46,704,201–46,735,375, reverse strandPLA2G7ANKRD66: 46,746,922–46,759,790, forward strandANKRD66MEP1A: 46,793,368–46,846,488, forward strandMEP1AADGRF5: 46,852,310–46,956,392, reverse strandADGRF5ADGRF1: 46,997,708–47,042,368, reverse strandADGRF1Diagram of PLA2G7: 12 exons on the reverse strand of chromosome 6Exon 12: 46,704,201–46,704,696, 496 basesExon 11: 46,705,153–46,705,301, 149 basesExon 10: 46,707,991–46,708,161, 171 basesExon 9: 46,709,327–46,709,418, 92 basesExon 8: 46,710,545–46,710,658, 114 basesExon 7: 46,711,496–46,711,619, 124 basesExon 6: 46,712,269–46,712,337, 69 basesExon 5: 46,714,460–46,714,553, 94 basesExon 4: 46,716,384–46,716,528, 145 basesExon 3: 46,716,975–46,717,096, 122 basesExon 2: 46,722,783–46,722,925, 143 basesExon 1: 46,735,180–46,735,375, 196 bases1211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 31.2 kb; 1,326 of those bases code for the protein.

How a genome test reads PLA2G7

3

positions in PLA2G7 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 31.2 kb of PLA2G7, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PLA2G7 gene: phospholipase A2 group VII. Retrieved 17 October 2026, from https://dantelabs.com/genes/pla2g7

Vancouver

Dante Labs. PLA2G7 gene: phospholipase A2 group VII [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pla2g7

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