Traits

Traits linked to NLGN4X

neuroligin 4 X-linked

The Human Phenotype Ontology links 16 traits to NLGN4X, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Autism spectrum disorder	Often (30–79%)
EEG abnormality	Often (30–79%)
Epilepsy	Often (30–79%)
Intellectual disability, mild	Often (30–79%)
Autism	Not recorded
Delayed speech and language development	Not recorded
Impaired use of nonverbal behaviors	Not recorded
Inflexible adherence to routines	Not recorded
Intellectual disability	Not recorded
Lack of peer relationships	Not recorded
Lack of spontaneous play	Not recorded
Reduced ability to form peer relationships	Not recorded
Repetitive movements	Not recorded
Restrictive behavior	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Asymmetry of the posterior head	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Increased serum serotonin	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NLGN4X and how often each is seen. Find out more at hpo.jax.org.

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