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Gene

MAP4K4

mitogen-activated protein kinase kinase kinase kinase 4

Summary

Cytogenetic location
2q11.2
Coordinates
Chromosome 2: 101,697,707–101,894,690 (GRCh38)
Exons
33 exons across 197 kb
Protein
1,384 amino acids
Also known as
HGK, NIK, FLH21957
MANE Select transcript
ENST00000324219.9NM_001395002.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MAP4K4 yet. The test sequences your whole genome, so your data includes it all the same.

How MAP4K4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 2, with a bracket where MAP4K4 sits. MAP4K4 and 6 genes near it on chromosome 2, from 101,296,199 to 102,296,198.Chromosome 22q11.2p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3101.4 Mb101.6 Mb101.8 Mb102 Mb102.2 MbRNF149: 101,271,215–101,308,770, reverse strandRNF149CREG2: 101,345,550–101,387,697, reverse strandCREG2RFX8: 101,397,359–101,475,112, reverse strandRFX8MAP4K4: 101,697,707–101,894,690, forward strandMAP4K4IL1R2: 101,991,798–102,029,084, forward strandIL1R2IL1R1: 102,063,933–102,179,874, forward strandIL1R1IL36R: 102,186,965–102,240,004, forward strandIL36RDiagram of MAP4K4: 33 exons on the forward strand of chromosome 2Exon 28: 1 known disease-causing siteExon 1: 101,697,707–101,698,137, 431 basesExon 2: 101,698,473–101,698,538, 66 basesExon 3: 101,790,720–101,790,776, 57 basesExon 4: 101,823,928–101,824,053, 126 basesExon 5: 101,825,319–101,825,429, 111 basesExon 6: 101,829,504–101,829,594, 91 basesExon 7: 101,831,721–101,831,851, 131 basesExon 8: 101,834,409–101,834,463, 55 basesExon 9: 101,835,900–101,835,978, 79 basesExon 10: 101,839,819–101,839,994, 176 basesExon 11: 101,842,609–101,842,681, 73 basesExon 12: 101,844,101–101,844,311, 211 basesExon 13: 101,855,977–101,856,138, 162 basesExon 14: 101,858,996–101,859,082, 87 basesExon 15: 101,859,643–101,859,864, 222 basesExon 16: 101,860,825–101,860,986, 162 basesExon 17: 101,863,821–101,864,051, 231 basesExon 18: 101,864,930–101,865,036, 107 basesExon 19: 101,866,428–101,866,579, 152 basesExon 20: 101,867,212–101,867,309, 98 basesExon 21: 101,868,029–101,868,037, 9 basesExon 22: 101,869,622–101,869,797, 176 basesExon 23: 101,870,295–101,870,415, 121 basesExon 24: 101,871,494–101,871,685, 192 basesExon 25: 101,873,647–101,873,764, 118 basesExon 26: 101,874,082–101,874,252, 171 basesExon 27: 101,877,003–101,877,146, 144 basesExon 28: 101,882,551–101,882,685, 135 basesExon 29: 101,885,187–101,885,287, 101 basesExon 30: 101,887,088–101,887,237, 150 basesExon 31: 101,887,778–101,887,937, 160 basesExon 32: 101,888,796–101,888,935, 140 basesExon 33: 101,891,166–101,894,690, 3,525 bases151015202530335′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8 kb of the gene's 197 kb; 4,155 of those bases code for the protein.

How a genome test reads MAP4K4

1

position in MAP4K4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 197 kb of MAP4K4, introns included, not only the 8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAP4K4 gene: mitogen-activated protein kinase kinase kinase kinase 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/map4k4

Vancouver

Dante Labs. MAP4K4 gene: mitogen-activated protein kinase kinase kinase kinase 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/map4k4

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