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Gene

LPP

LIM domain containing preferred translocation partner in lipoma

Summary

Cytogenetic location
3q27.3-q28
Coordinates
Chromosome 3: 188,154,157–188,890,671 (GRCh38)
Exons
12 exons across 736.5 kb
Protein
612 amino acids
MANE Select transcript
ENST00000617246.5NM_001375462.1
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads LPP yet. The test sequences your whole genome, so your data includes it all the same.

How LPP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where LPP sits. LPP and 4 genes near it on chromosome 3, from 187,417,642 to 189,627,186.Chromosome 33q27.3-q28p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q29187.5 Mb188 Mb188.5 Mb189 Mb189.5 MbSST: 187,668,856–187,670,401, reverse strandSSTRTP2: 187,698,259–187,702,656, reverse strandRTP2BCL6: 187,721,377–187,745,725, reverse strandBCL6LPP: 188,154,157–188,890,671, forward strandLPPTPRG1: 188,947,165–189,325,304, forward strandTPRG1Diagram of LPP: 12 exons on the forward strand of chromosome 3Exon 9: 1 known disease-causing siteExon 1: 188,154,157–188,154,252, 96 basesExon 2: 188,225,405–188,225,527, 123 basesExon 3: 188,341,663–188,341,719, 57 basesExon 4: 188,406,112–188,406,313, 202 basesExon 5: 188,484,592–188,484,704, 113 basesExon 6: 188,524,665–188,524,787, 123 basesExon 7: 188,609,161–188,609,844, 684 basesExon 8: 188,708,267–188,708,393, 127 basesExon 9: 188,760,113–188,760,282, 170 basesExon 10: 188,866,200–188,866,378, 179 basesExon 11: 188,872,643–188,872,763, 121 basesExon 12: 188,874,351–188,890,671, 16,321 bases1125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 18.3 kb of the gene's 736.5 kb; 1,839 of those bases code for the protein.

Sequencing LPP

3Low

How hard LPP is to sequence with short reads, out of 100

  • Mappability5%
  • Homology0%
  • Repeats5.2%
  • GC content6.5%
  • Reference coverage0%

1

position in LPP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 736.5 kb of LPP, introns included, not only the 18.3 kb of exons.

Traits linked to LPP

The Human Phenotype Ontology lists these as features of the rare conditions LPP can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). LPP gene: LIM domain containing preferred translocation partner in lipoma. Retrieved 17 October 2026, from https://dantelabs.com/genes/lpp

Vancouver

Dante Labs. LPP gene: LIM domain containing preferred translocation partner in lipoma [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lpp

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