Traits

Traits linked to LINS1

lines homolog 1

The Human Phenotype Ontology links 11 traits to LINS1, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent speech development	Always
Global developmental delay	Always
Intellectual disability	Always
Aggressive behavior	Often (30–79%)
Persistent head lag	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Midface retrusion	Always
Depressed nasal bridge	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Often (30–79%)
Growth delay	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to LINS1 and how often each is seen. Find out more at hpo.jax.org.

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