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Gene

JAM3

junctional adhesion molecule 3

Summary

Cytogenetic location
11q25
Coordinates
Chromosome 11: 134,069,072–134,152,001 (GRCh38)
Exons
9 exons across 82.9 kb
Protein
310 amino acids
Also known as
JAM-C, JAMC, JAM-3
MANE Select transcript
ENST00000299106.9NM_032801.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads JAM3 yet. The test sequences your whole genome, so your data includes it all the same.

How JAM3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where JAM3 sits. JAM3 and 9 genes near it on chromosome 11, from 133,610,537 to 134,610,536.Chromosome 1111q25p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25133.8 Mb134 Mb134.2 Mb134.4 Mb134.6 MbSPATA19: 133,840,631–133,845,538, reverse strandSPATA19IGSF9B: 133,896,438–133,957,022, reverse strandIGSF9BJAM3: 134,069,072–134,152,001, forward strandJAM3NCAPD3: 134,149,039–134,225,504, reverse strandNCAPD3VPS26B: 134,224,613–134,247,794, forward strandVPS26BTHYN1: 134,247,921–134,253,373, reverse strandTHYN1ACAD8: 134,253,510–134,267,494, forward strandACAD8GLB1L3: 134,274,245–134,319,579, forward strandGLB1L3GLB1L2: 134,331,886–134,378,341, forward strandGLB1L2B3GAT1: 134,378,504–134,412,250, reverse strandB3GAT1Diagram of JAM3: 9 exons on the forward strand of chromosome 11Exon 1: 2 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 1: 134,069,072–134,069,159, 88 basesExon 2: 134,139,851–134,139,916, 66 basesExon 3: 134,140,657–134,140,770, 114 basesExon 4: 134,144,241–134,144,393, 153 basesExon 5: 134,144,792–134,144,994, 203 basesExon 6: 134,145,946–134,146,045, 100 basesExon 7: 134,148,547–134,148,676, 130 basesExon 8: 134,148,764–134,148,818, 55 basesExon 9: 134,149,146–134,152,001, 2,856 bases1246895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.8 kb of the gene's 82.9 kb; 933 of those bases code for the protein.

Sequencing JAM3

10

positions in JAM3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 82.9 kb of JAM3, introns included, not only the 3.8 kb of exons.

Traits linked to JAM3

The Human Phenotype Ontology lists these as features of the rare conditions JAM3 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). JAM3 gene: junctional adhesion molecule 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/jam3

Vancouver

Dante Labs. JAM3 gene: junctional adhesion molecule 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/jam3

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