{
  "url": "https://dantelabs.com/genes/jam3",
  "gene": {
    "slug": "jam3",
    "symbol": "JAM3",
    "name": "junctional adhesion molecule 3",
    "hgnc": "HGNC:15532",
    "summary": null,
    "location": "11q25",
    "locusType": "gene with protein product",
    "aliases": [
      "JAM-C",
      "JAMC",
      "JAM-3"
    ],
    "previousSymbols": [],
    "ensemblId": "ENSG00000166086",
    "entrezId": 83700,
    "omim": [
      "606871"
    ],
    "uniprot": [
      "Q9BX67"
    ],
    "model": {
      "build": "GRCh38",
      "release": "v1.5",
      "chrom": "11",
      "start": 134069072,
      "end": 134152001,
      "strand": "+",
      "ensemblTranscript": "ENST00000299106.9",
      "refseqTranscript": "NM_032801.5",
      "ensemblProtein": "ENSP00000299106.4",
      "refseqProtein": "NP_116190.3",
      "exons": [
        {
          "start": 134069072,
          "end": 134069159
        },
        {
          "start": 134139851,
          "end": 134139916
        },
        {
          "start": 134140657,
          "end": 134140770
        },
        {
          "start": 134144241,
          "end": 134144393
        },
        {
          "start": 134144792,
          "end": 134144994
        },
        {
          "start": 134145946,
          "end": 134146045
        },
        {
          "start": 134148547,
          "end": 134148676
        },
        {
          "start": 134148764,
          "end": 134148818
        },
        {
          "start": 134149146,
          "end": 134152001
        }
      ],
      "cds": {
        "start": 134069084,
        "end": 134149181
      }
    },
    "grch37": {
      "build": "GRCh37",
      "release": "87",
      "chrom": "11",
      "start": 133938820,
      "end": 134021896,
      "strand": "+"
    },
    "neighbourhood": {
      "release": "116",
      "start": 133610537,
      "end": 134610536,
      "genes": [
        {
          "symbol": "SPATA19",
          "ensemblId": "ENSG00000166118",
          "biotype": "protein_coding",
          "start": 133840631,
          "end": 133845538,
          "strand": "-",
          "slug": "spata19"
        },
        {
          "symbol": "IGSF9B",
          "ensemblId": "ENSG00000080854",
          "biotype": "protein_coding",
          "start": 133896438,
          "end": 133957022,
          "strand": "-",
          "slug": "igsf9b"
        },
        {
          "symbol": "NCAPD3",
          "ensemblId": "ENSG00000151503",
          "biotype": "protein_coding",
          "start": 134149039,
          "end": 134225504,
          "strand": "-",
          "slug": "ncapd3"
        },
        {
          "symbol": "VPS26B",
          "ensemblId": "ENSG00000151502",
          "biotype": "protein_coding",
          "start": 134224613,
          "end": 134247794,
          "strand": "+",
          "slug": "vps26b"
        },
        {
          "symbol": "THYN1",
          "ensemblId": "ENSG00000151500",
          "biotype": "protein_coding",
          "start": 134247921,
          "end": 134253373,
          "strand": "-",
          "slug": "thyn1"
        },
        {
          "symbol": "ACAD8",
          "ensemblId": "ENSG00000151498",
          "biotype": "protein_coding",
          "start": 134253510,
          "end": 134267494,
          "strand": "+",
          "slug": "acad8"
        },
        {
          "symbol": "GLB1L3",
          "ensemblId": "ENSG00000166105",
          "biotype": "protein_coding",
          "start": 134274245,
          "end": 134319579,
          "strand": "+",
          "slug": "glb1l3"
        },
        {
          "symbol": "GLB1L2",
          "ensemblId": "ENSG00000149328",
          "biotype": "protein_coding",
          "start": 134331886,
          "end": 134378341,
          "strand": "+",
          "slug": "glb1l2"
        },
        {
          "symbol": "B3GAT1",
          "ensemblId": "ENSG00000109956",
          "biotype": "protein_coding",
          "start": 134378504,
          "end": 134412250,
          "strand": "-",
          "slug": "b3gat1"
        }
      ],
      "truncated": false
    },
    "reports": [],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "ectopic-kidney",
        "name": "Abnormal kidney location",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/ectopic-kidney"
      },
      {
        "slug": "microphthalmia",
        "name": "Abnormally small eyeball",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/microphthalmia"
      },
      {
        "slug": "cataract",
        "name": "Clouding of the lens of the eye",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/cataract"
      },
      {
        "slug": "cystic-renal-dysplasia",
        "name": "Cystic renal dysplasia",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cystic-renal-dysplasia"
      },
      {
        "slug": "secondary-microcephaly",
        "name": "Development of small head that was not present at birth",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/secondary-microcephaly"
      },
      {
        "slug": "hepatomegaly",
        "name": "Enlarged liver",
        "systems": [
          "abnormality-of-the-digestive-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/hepatomegaly"
      },
      {
        "slug": "seizure",
        "name": "Epilepsy",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/seizure"
      },
      {
        "slug": "global-developmental-delay",
        "name": "Global developmental delay",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/global-developmental-delay"
      },
      {
        "slug": "ventricular-septal-defect",
        "name": "Hole in heart wall separating two lower heart chambers",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/ventricular-septal-defect"
      },
      {
        "slug": "hyperreflexia",
        "name": "Increased reflexes",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/hyperreflexia"
      },
      {
        "slug": "spasticity",
        "name": "Involuntary muscle stiffness, contraction, or spasm",
        "systems": [
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "obligate",
        "url": "https://dantelabs.com/traits/spasticity"
      },
      {
        "slug": "optic-disc-pallor",
        "name": "Optic disc pallor",
        "systems": [
          "abnormality-of-the-eye"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/optic-disc-pallor"
      },
      {
        "slug": "cerebellar-hypoplasia",
        "name": "Small cerebellum",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "frequency": "occasional",
        "url": "https://dantelabs.com/traits/cerebellar-hypoplasia"
      },
      {
        "slug": "cryptorchidism",
        "name": "Undescended testes",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "frequency": "frequent",
        "url": "https://dantelabs.com/traits/cryptorchidism"
      },
      {
        "slug": "ventriculomegaly",
        "name": "Ventriculomegaly",
        "systems": [
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/ventriculomegaly"
      }
    ],
    "related": [],
    "sources": null,
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}