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Gene

ICMT

isoprenylcysteine carboxyl methyltransferase

Summary

Cytogenetic location
1p36.31
Coordinates
Chromosome 1: 6,221,193–6,235,964 (GRCh38)
Exons
5 exons across 14.8 kb
Protein
284 amino acids
Also known as
PCCMT, HSTE14, PPMT
MANE Select transcript
ENST00000343813.10NM_012405.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads ICMT yet. The test sequences your whole genome, so your data includes it all the same.

How ICMT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where ICMT sits. ICMT and 20 genes near it on chromosome 1, from 5,728,579 to 6,728,578.Chromosome 11p36.31p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q445.8 Mb6 Mb6.2 Mb6.4 Mb6.6 MbNPHP4: 5,862,804–5,993,455, reverse strandNPHP4KCNAB2: 5,990,927–6,101,193, forward strandKCNAB2CHD5: 6,101,787–6,180,356, reverse strandCHD5: 6,159,430–6,197,757, reverse strandRPL22: 6,185,020–6,209,389, reverse strandRPL22RNF207: 6,205,392–6,224,634, forward strandRNF207ICMT: 6,221,193–6,235,964, reverse strandICMTHES3: 6,241,481–6,246,656, forward strandHES3GPR153: 6,247,347–6,261,104, reverse strandGPR153ACOT7: 6,264,268–6,393,789, reverse strandACOT7HES2: 6,412,418–6,424,690, reverse strandHES2ESPN: 6,424,770–6,461,367, forward strandESPNTNFRSF25: 6,460,786–6,466,190, reverse strandTNFRSF25PLEKHG5: 6,467,122–6,520,074, reverse strandPLEKHG5NOL9: 6,521,347–6,554,536, reverse strandNOL9TAS1R1: 6,555,303–6,579,755, forward strandTAS1R1ZBTB48: 6,579,994–6,589,290, forward strandZBTB48KLHL21: 6,590,724–6,614,607, reverse strandKLHL21PHF13: 6,613,723–6,624,030, forward strandPHF13THAP3: 6,624,845–6,635,612, forward strandTHAP3DNAJC11: 6,634,167–6,701,924, reverse strandDNAJC11Diagram of ICMT: 5 exons on the reverse strand of chromosome 1Exon 5: 6,221,193–6,225,262, 4,070 basesExon 4: 6,231,902–6,232,119, 218 basesExon 3: 6,233,474–6,233,643, 170 basesExon 2: 6,234,886–6,234,974, 89 basesExon 1: 6,235,717–6,235,964, 248 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.8 kb of the gene's 14.8 kb; 855 of those bases code for the protein.

Sequencing ICMT

1Low

How hard ICMT is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats2.5%
  • GC content5.2%
  • Reference coverage0%

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.

Cite this page

APA

Dante Labs. (n.d.). ICMT gene: isoprenylcysteine carboxyl methyltransferase. Retrieved 17 October 2026, from https://dantelabs.com/genes/icmt

Vancouver

Dante Labs. ICMT gene: isoprenylcysteine carboxyl methyltransferase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/icmt

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