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Gene

FRG2

FSHD region gene 2

Summary

Cytogenetic location
4q35.2
Coordinates
Chromosome 4: 190,024,367–190,027,256 (GRCh38)
Exons
4 exons across 2.9 kb
Protein
279 amino acids
Also known as
FRG2A
MANE Select transcript
ENST00000504750.6NM_001286820.2
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads FRG2 yet. The test sequences your whole genome, so your data includes it all the same.

How FRG2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where FRG2 sits. FRG2 and 3 genes near it on chromosome 4, from 189,525,812 to 190,525,811.Chromosome 44q35.2p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2189.6 Mb189.8 Mb190 Mb190.2 Mb190.4 MbFRG1: 189,940,818–189,963,207, forward strandFRG1DUX4L9: 190,019,718–190,022,665, reverse strandDUX4L9FRG2: 190,024,367–190,027,256, reverse strandFRG2DUX4: 190,173,774–190,196,133, forward strandDUX4Diagram of FRG2: 4 exons on the reverse strand of chromosome 4Exon 4: 190,024,367–190,026,066, 1,700 basesExon 3: 190,026,384–190,026,461, 78 basesExon 2: 190,026,691–190,026,768, 78 basesExon 1: 190,027,027–190,027,256, 230 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 2.9 kb; 840 of those bases code for the protein.

Sequencing FRG2

69Hard

How hard FRG2 is to sequence with short reads, out of 100

Much of FRG2 sits where short reads can miss or misplace a change.

What adds to it: the share of FRG2's exons in each kind of hard region

  • Mappability100%
  • Homology100%
  • Repeats2.5%
  • GC content33%
  • Reference coverage0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.

Cite this page

APA

Dante Labs. (n.d.). FRG2 gene: FSHD region gene 2. Retrieved 18 October 2026, from https://dantelabs.com/genes/frg2

Vancouver

Dante Labs. FRG2 gene: FSHD region gene 2 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/frg2

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