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Risk score · Metabolism & body

Type 2 Diabetes Polygenic Risk Score

Type 2 diabetes is when the body stops responding well to insulin. Weight, diet and activity are the main risk factors, and genetics adds to them.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Type 2 diabetes (T2D)

Genetic variants

384

Method

Genome-wide significant variants

Built from studies of

European 100%

Evaluated in

European 46%, South Asian 36%, Greater Middle Eastern 18%

Published

Aly DM et al. (2021). Genome-wide association analyses highlight etiological differences underlying newly defined subtypes of diabetes Nat Genet.

The score in the PGS Catalog →

References

  1. Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, 2018. Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nat Genet

Other metabolism & body risk scores

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

From $449

Free shipping · Results in 6–8 weeks

Get my Genome Test