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Risk score · Mental health & wellbeing

Neuroticism Polygenic Score

Neuroticism is a personality trait describing how strongly someone tends to experience negative emotions like worry, guilt or irritability.

A risk score adds up many common variants, each with a small effect, into an estimate of genetic predisposition. It is not a diagnosis.

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A polygenic score for Neuroticism

Genetic variants

3,578

Method

Pruning and Thresholding (P+T)

Built from studies of

European 100%

Evaluated in

African 25%, East Asian 25%, European 25%, South Asian 25%

Published

Weissbrod O et al. (2022). Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores. Nat Genet.

The score in the PGS Catalog →

References

  1. Bycroft C, Freeman C, Petkova D, Band G, Elliott LT, Sharp K, 2018. The UK Biobank resource with deep phenotyping and genomic data. Nature

Other mental health & wellbeing risk scores

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One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. Physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.

From $449

Free shipping · Results in 6–8 weeks

Get my Genome Test