Trait

Increased wrist mobility

Clinical name: Wrist hypermobility

The ability of the wrist joints to move beyond their normal range of motion.

HPO HP:0005072

Also called: Hyperextensibility at wrists, Increased laxity of wrists
Body system: Abnormality of the musculoskeletal system

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7 genes linked to Increased wrist mobility

Changes in these genes cause rare conditions in which Increased wrist mobility is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
COL12A1collagen type XII alpha 1 chain	Very often (80–99%)	In 1 condition
COL6A1collagen type VI alpha 1 chain	Very often (80–99%)	In 2 conditions
COL6A2collagen type VI alpha 2 chain	Very often (80–99%)	In 1 condition
COL6A3collagen type VI alpha 3 chain	Very often (80–99%)	In 1 condition
HYAL1hyaluronidase 1	Often (30–79%)	In 1 condition
PYCR2pyrroline-5-carboxylate reductase 2	Sometimes (5–29%)	In 1 condition
RNF13ring finger protein 13	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Small joint hypermobility

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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