Trait
Trichorrhexis nodosa
Trichorrhexis nodosa is the formation of nodes along the hair shaft through which breakage readily occurs. It is thus a focal defect in the hair fiber that is characterized by thickening or weak points (nodes) that cause the hair to break off easily. The result is defective, abnormally fragile hair.
Summary
- Body system
- Abnormality of the integument
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test14 genes linked to Trichorrhexis nodosa
Changes in these genes cause rare conditions in which Trichorrhexis nodosa is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Always | In 1 condition |
| GTF2H5general transcription factor IIH subunit 5 | Always | In 1 condition |
| HEPHL1hephaestin like 1 | Always | In 1 condition |
| MPLKIPM-phase specific PLK1 interacting protein | Always | In 1 condition |
| SKIC2SKI2 subunit of superkiller complex | Always | In 2 conditions |
| SKIC3SKI3 subunit of superkiller complex | Always | In 2 conditions |
| AARS1alanyl-tRNA synthetase 1 | Often (30–79%) | In 1 condition |
| CLCN6Cl-/H+ antiporter 6 | Often (30–79%) | In 1 condition |
| PORCNporcupine O-acyltransferase | Often (30–79%) | In 1 condition |
| SPINK5serine peptidase inhibitor Kazal type 5 | Often (30–79%) | In 2 conditions |
| ASLargininosuccinate lyase | Sometimes (5–29%) | In 2 conditions |
| GJA1gap junction protein alpha 1 | Sometimes (5–29%) | In 1 condition |
| KDF1keratinocyte differentiation factor 1 | Sometimes (5–29%) | In 1 condition |
| KRT25keratin 25 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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