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Trait

Reduced kininogen activity

Amount or activity of kininogen is below the lower limit of normal. Kininogen functions as a cofactor in the contact phase of the intrinsic blood coagulation cascade.

HPO HP:0005527

Summary

Also called
Fitzgerald factor deficiency, Kininogen deficiency, Williams factor deficiency, Williams-Fitzgerald-Flaujeac factor deficiency
Body system
Abnormality of blood and blood-forming tissuesLaboratory abnormality

1 gene linked to Reduced kininogen activity

Changes in these genes cause rare conditions in which Reduced kininogen activity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
KNG1kininogen 1Not recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal kinin-kallikrein system component activityAbnormality of the intrinsic pathway

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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