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Trait

Impaired memory B cell generation

Impaired production of memory cells, the B cells that persist for years or an entire lifetime and which confer rapid and enhanced response to secondary challenge.

HPO HP:0002847

Summary

Body system
Abnormal cellular phenotypeAbnormality of blood and blood-forming tissuesLaboratory abnormalityAbnormality of the immune system

2 genes linked to Impaired memory B cell generation

Changes in these genes cause rare conditions in which Impaired memory B cell generation is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
CD40CD40 moleculeNot recordedIn 1 condition
CD40LGCD40 ligandNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of B cell physiology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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