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Trait

Capillary leak

An acute phenomenon characterized by hypotension and anasarca due to the loss of plasma volume into peripheral tissues, with evidence of decreased plasma volume (hemoconcentration) and protein loss from the intravascular space (hypoalbuminemia) during acute episodes.

HPO HP:0030005

Summary

Also called
Increased capillary permeability
Body system
Abnormality of the cardiovascular system

2 genes linked to Capillary leak

Changes in these genes cause rare conditions in which Capillary leak is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
LCKLCK proto-oncogene, Src family tyrosine kinaseAlwaysIn 1 condition
FSHRfollicle stimulating hormone receptorVery often (80–99%)In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal capillary physiology

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

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