Trait

Acute middle ear infection

Clinical name: Acute otitis media

Acute otitis media is a short and generally painful infection of the middle ear.

HPO HP:0000371

Body system: Abnormality of the ear Abnormality of the immune system

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5 genes linked to Acute middle ear infection

Changes in these genes cause rare conditions in which Acute middle ear infection is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
CIITAclass II major histocompatibility complex transactivator	Sometimes (5–29%)	In 1 condition
JAK3Janus kinase 3	Sometimes (5–29%)	In 1 condition
RFX5regulatory factor X5	Sometimes (5–29%)	In 1 condition
RFXANKregulatory factor X associated ankyrin containing protein	Sometimes (5–29%)	In 1 condition
RFXAPregulatory factor X associated protein	Sometimes (5–29%)	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Middle ear infection

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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