Trait

Acrokeratosis

Overgrowth of the stratum corneum characterized by flesh-coloured or slightly pigmented smooth or warty papules on the upper surface of hands and feet.

HPO HP:0200016

Also called: Acral keratosis
Body system: Abnormality of the integument

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3 genes linked to Acrokeratosis

Changes in these genes cause rare conditions in which Acrokeratosis is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LTV1LTV1 ribosome biogenesis factor	Always	In 1 condition
ATP2A2ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Very often (80–99%)	In 3 conditions
PTENphosphatase and tensin homolog	Often (30–79%)	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Epidermal thickening Skin nodule

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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