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Gene

TLR5

toll like receptor 5

Summary

Cytogenetic location
1q41
Coordinates
Chromosome 1: 223,109,404–223,143,248 (GRCh38)
Exons
6 exons across 33.8 kb
Protein
858 amino acids
Also known as
TIL3, FLJ10052, MGC126430, MGC126431
Previous symbols
SLEB1
MANE Select transcript
ENST00000642603.2NM_003268.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TLR5 yet. The test sequences your whole genome, so your data includes it all the same.

How TLR5 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where TLR5 sits. TLR5 and 8 genes near it on chromosome 1, from 222,626,326 to 223,626,325.Chromosome 11q41p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44222.8 Mb223 Mb223.2 Mb223.4 Mb223.6 MbMIA3: 222,618,040–222,668,171, forward strandMIA3AIDA: 222,668,013–222,713,210, reverse strandAIDABROX: 222,711,480–222,735,927, forward strandBROXFAM177B: 222,737,202–222,753,157, forward strandFAM177BDISP1: 222,814,730–223,009,398, forward strandDISP1TLR5: 223,109,404–223,143,248, reverse strandTLR5SUSD4: 223,220,819–223,365,279, reverse strandSUSD4CCDC185: 223,393,415–223,395,465, forward strandCCDC185CAPN8: 223,538,007–223,665,737, reverse strandCAPN8Diagram of TLR5: 6 exons on the reverse strand of chromosome 1Exon 6: 1 known disease-causing siteExon 6: 223,109,404–223,113,035, 3,632 basesExon 5: 223,132,475–223,132,639, 165 basesExon 4: 223,134,682–223,134,864, 183 basesExon 3: 223,137,178–223,137,263, 86 basesExon 2: 223,141,648–223,141,763, 116 basesExon 1: 223,143,196–223,143,248, 53 bases6543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 33.8 kb; 2,577 of those bases code for the protein.

How a genome test reads TLR5

1

position in TLR5 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 33.8 kb of TLR5, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TLR5 gene: toll like receptor 5. Retrieved 17 October 2026, from https://dantelabs.com/genes/tlr5

Vancouver

Dante Labs. TLR5 gene: toll like receptor 5 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tlr5

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