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Gene

TLE4

TLE family member 4, transcriptional corepressor

Summary

Cytogenetic location
9q21.31
Coordinates
Chromosome 9: 79,571,965–79,726,882 (GRCh38)
Exons
20 exons across 154.9 kb
Protein
773 amino acids
Also known as
E(spl), ESG, GRG4
MANE Select transcript
ENST00000376552.8NM_007005.6
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads TLE4 yet. The test sequences your whole genome, so your data includes it all the same.

How TLE4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 9, with a bracket where TLE4 sits. TLE4 and 0 genes near it on chromosome 9, from 79,149,424 to 80,149,423.Chromosome 99q21.31p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.379.2 Mb79.4 Mb79.6 Mb79.8 Mb80 MbTLE4: 79,571,965–79,726,882, forward strandTLE4Diagram of TLE4: 20 exons on the forward strand of chromosome 9Exon 1: 79,571,965–79,572,835, 871 basesExon 2: 79,573,689–79,573,786, 98 basesExon 3: 79,574,873–79,574,936, 64 basesExon 4: 79,576,133–79,576,177, 45 basesExon 5: 79,612,656–79,612,718, 63 basesExon 6: 79,627,374–79,627,448, 75 basesExon 7: 79,652,593–79,652,794, 202 basesExon 8: 79,654,059–79,654,075, 17 basesExon 9: 79,704,783–79,704,902, 120 basesExon 10: 79,705,889–79,705,942, 54 basesExon 11: 79,706,747–79,706,899, 153 basesExon 12: 79,708,118–79,708,250, 133 basesExon 13: 79,708,593–79,708,786, 194 basesExon 14: 79,709,623–79,709,699, 77 basesExon 15: 79,718,722–79,718,971, 250 basesExon 16: 79,720,046–79,720,293, 248 basesExon 17: 79,721,741–79,721,888, 148 basesExon 18: 79,722,451–79,722,601, 151 basesExon 19: 79,722,959–79,723,035, 77 basesExon 20: 79,725,037–79,726,882, 1,846 bases151015205′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 154.9 kb; 2,322 of those bases code for the protein.

Sequencing TLE4

5Easy

How hard TLE4 is to sequence with short reads, out of 100

Almost all of TLE4's exons sit where short reads map cleanly.

What adds to it: the share of TLE4's exons in each kind of hard region

  • Mappability0.2%
  • Homology0%
  • Shared with chrY0%
  • Reference coverage0%
  • Repeats8.3%
  • GC content10%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.

Cite this page

APA

Dante Labs. (n.d.). TLE4 gene: TLE family member 4, transcriptional corepressor. Retrieved 21 October 2026, from https://dantelabs.com/genes/tle4

Vancouver

Dante Labs. TLE4 gene: TLE family member 4, transcriptional corepressor [Internet]. [cited 21 October 2026]. Available from: https://dantelabs.com/genes/tle4

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