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Gene

TEAD3

TEA domain transcription factor 3

Summary

Cytogenetic location
6p21.31
Coordinates
Chromosome 6: 35,473,597–35,497,079 (GRCh38)
Exons
13 exons across 23.5 kb
Protein
435 amino acids
Also known as
TEF-5, ETFR-1
Previous symbols
TEAD5
MANE Select transcript
ENST00000338863.13NM_003214.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads TEAD3 yet. The test sequences your whole genome, so your data includes it all the same.

How TEAD3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 6, with a bracket where TEAD3 sits. TEAD3 and 17 genes near it on chromosome 6, from 34,985,338 to 35,985,337.Chromosome 66p21.31p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2735 Mb35.2 Mb35.4 Mb35.6 Mb35.8 MbANKS1A: 34,889,243–35,091,421, forward strandANKS1ATCP11: 35,118,071–35,148,610, reverse strandTCP11SCUBE3: 35,213,859–35,253,080, forward strandSCUBE3ZNF76: 35,258,909–35,295,985, forward strandZNF76DEF6: 35,297,818–35,321,909, forward strandDEF6PPARD: 35,342,530–35,428,193, forward strandPPARDFANCE: 35,452,315–35,467,106, forward strandFANCERPL10A: 35,468,366–35,470,786, forward strandRPL10ATEAD3: 35,473,597–35,497,079, reverse strandTEAD3TULP1: 35,497,874–35,512,941, reverse strandTULP1FKBP5: 35,572,945–35,728,622, reverse strandFKBP5ARMC12: 35,737,028–35,749,079, forward strandARMC12CLPSL2: 35,776,535–35,779,557, forward strandCLPSL2CLPSL1: 35,781,019–35,793,675, forward strandCLPSL1CLPS: 35,794,982–35,798,251, reverse strandCLPSLHFPL5: 35,797,206–35,845,397, forward strandLHFPL5SRPK1: 35,832,966–35,921,342, reverse strandSRPK1SLC26A8: 35,943,516–36,028,767, reverse strandSLC26A8Diagram of TEAD3: 13 exons on the reverse strand of chromosome 6Exon 13: 35,473,597–35,475,157, 1,561 basesExon 12: 35,475,336–35,475,488, 153 basesExon 11: 35,475,566–35,475,706, 141 basesExon 10: 35,475,919–35,476,092, 174 basesExon 9: 35,476,302–35,476,435, 134 basesExon 8: 35,477,311–35,477,372, 62 basesExon 7: 35,478,275–35,478,324, 50 basesExon 6: 35,478,434–35,478,571, 138 basesExon 5: 35,479,305–35,479,316, 12 basesExon 4: 35,480,312–35,480,374, 63 basesExon 3: 35,484,560–35,484,624, 65 basesExon 2: 35,486,461–35,486,711, 251 basesExon 1: 35,496,898–35,497,079, 182 bases131210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3 kb of the gene's 23.5 kb; 1,308 of those bases code for the protein.

Sequencing TEAD3

2Easy

How hard TEAD3 is to sequence with short reads, out of 100

Almost all of TEAD3's exons sit where short reads map cleanly.

What adds to it: the share of TEAD3's exons in each kind of hard region

  • Mappability0%
  • Homology0%
  • Repeats4.6%
  • GC content15%
  • Reference coverage0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

1

position in TEAD3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 23.5 kb of TEAD3, introns included, not only the 3 kb of exons.

ClinVar pathogenic variants (1)

The TEAD3 variants ClinVar classifies pathogenic or likely pathogenic for any condition, reviewed by at least one submitter with criteria, and the most reviewed of them. It is ClinVar's public record of the gene, never a result.

  • Pathogenic 1
VariantConditionsClinVar classificationReview status
NM_003322.6(TULP1):c.1471T>C (p.Phe491Leu) (opens in a new tab)Leber congenital amaurosis and 1 otherPathogenic1 star out of 4 criteria provided, single submitter

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). TEAD3 gene: TEA domain transcription factor 3. Retrieved 18 October 2026, from https://dantelabs.com/genes/tead3

Vancouver

Dante Labs. TEAD3 gene: TEA domain transcription factor 3 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/tead3

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