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Gene

RAPGEF6

Rap guanine nucleotide exchange factor 6

Summary

Cytogenetic location
5q31.1
Coordinates
Chromosome 5: 131,423,921–131,635,229 (GRCh38)
Exons
28 exons across 211.3 kb
Protein
1,601 amino acids
Also known as
RA-GEF-2, PDZ-GEF2
Previous symbols
PDZGEF2
MANE Select transcript
ENST00000509018.6NM_016340.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads RAPGEF6 yet. The test sequences your whole genome, so your data includes it all the same.

How RAPGEF6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 5, with a bracket where RAPGEF6 sits. RAPGEF6 and 8 genes near it on chromosome 5, from 131,029,575 to 132,029,574.Chromosome 55q31.1p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.3131.2 Mb131.4 Mb131.6 Mb131.8 Mb132 MbHINT1: 131,155,383–131,224,468, reverse strandHINT1LYRM7: 131,170,845–131,205,428, forward strandLYRM7CDC42SE2: 131,245,493–131,398,447, forward strandCDC42SE2RAPGEF6: 131,423,921–131,635,229, reverse strandRAPGEF6: 131,425,891–131,796,983, reverse strandFNIP1: 131,641,714–131,797,041, reverse strandFNIP1MEIKIN: 131,806,990–131,945,698, reverse strandMEIKIN: 131,807,143–132,011,637, reverse strandACSL6: 131,949,973–132,012,243, reverse strandACSL6Diagram of RAPGEF6: 28 exons on the reverse strand of chromosome 5Exon 28: 131,423,921–131,427,291, 3,371 basesExon 27: 131,428,902–131,429,216, 315 basesExon 26: 131,430,859–131,431,349, 491 basesExon 25: 131,433,430–131,433,658, 229 basesExon 24: 131,439,581–131,439,715, 135 basesExon 23: 131,442,349–131,442,537, 189 basesExon 22: 131,446,483–131,446,703, 221 basesExon 21: 131,453,054–131,453,177, 124 basesExon 20: 131,455,801–131,456,012, 212 basesExon 19: 131,461,705–131,462,088, 384 basesExon 18: 131,464,041–131,464,281, 241 basesExon 17: 131,472,587–131,472,744, 158 basesExon 16: 131,479,513–131,479,753, 241 basesExon 15: 131,489,546–131,489,654, 109 basesExon 14: 131,492,582–131,492,785, 204 basesExon 13: 131,495,553–131,495,660, 108 basesExon 12: 131,498,443–131,498,607, 165 basesExon 11: 131,504,626–131,504,778, 153 basesExon 10: 131,505,364–131,505,522, 159 basesExon 9: 131,508,071–131,508,207, 137 basesExon 8: 131,510,314–131,510,491, 178 basesExon 7: 131,521,390–131,521,521, 132 basesExon 6: 131,548,047–131,548,190, 144 basesExon 5: 131,561,978–131,562,047, 70 basesExon 4: 131,592,383–131,592,466, 84 basesExon 3: 131,603,271–131,603,327, 57 basesExon 2: 131,604,623–131,604,693, 71 basesExon 1: 131,634,962–131,635,229, 268 bases28262422201816141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.4 kb of the gene's 211.3 kb; 4,806 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). RAPGEF6 gene: Rap guanine nucleotide exchange factor 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/rapgef6

Vancouver

Dante Labs. RAPGEF6 gene: Rap guanine nucleotide exchange factor 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rapgef6

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