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Gene

PTGIS

prostaglandin I2 synthase

Summary

Cytogenetic location
20q13.13
Coordinates
Chromosome 20: 49,503,874–49,568,137 (GRCh38)
Exons
10 exons across 64.3 kb
Protein
500 amino acids
Also known as
PGIS, CYP8A1
MANE Select transcript
ENST00000244043.5NM_000961.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads PTGIS yet. The test sequences your whole genome, so your data includes it all the same.

How PTGIS is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 20, with a bracket where PTGIS sits. PTGIS and 11 genes near it on chromosome 20, from 49,036,006 to 50,036,005.Chromosome 2020q13.13p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3349.2 Mb49.4 Mb49.6 Mb49.8 Mb50 MbARFGEF2: 48,921,707–49,036,693, forward strandARFGEF2CSE1L: 49,046,246–49,097,033, forward strandCSE1LSTAU1: 49,113,324–49,188,417, reverse strandSTAU1DDX27: 49,219,347–49,244,077, forward strandDDX27ZNFX1: 49,237,946–49,278,473, reverse strandZNFX1KCNB1: 49,293,394–49,484,570, reverse strandKCNB1PTGIS: 49,503,874–49,568,137, reverse strandPTGISB4GALT5: 49,632,945–49,713,949, reverse strandB4GALT5SLC9A8: 49,812,677–49,892,242, forward strandSLC9A8SPATA2: 49,903,391–49,915,759, reverse strandSPATA2RNF114: 49,936,336–49,953,892, forward strandRNF114SNAI1: 49,982,979–49,988,886, forward strandSNAI1Diagram of PTGIS: 10 exons on the reverse strand of chromosome 20Exon 10: 49,503,874–49,508,064, 4,191 basesExon 9: 49,511,028–49,511,179, 152 basesExon 8: 49,513,080–49,513,261, 182 basesExon 7: 49,514,227–49,514,395, 169 basesExon 6: 49,524,058–49,524,239, 182 basesExon 5: 49,539,570–49,539,721, 152 basesExon 4: 49,544,305–49,544,448, 144 basesExon 3: 49,547,841–49,548,019, 179 basesExon 2: 49,550,066–49,550,189, 124 basesExon 1: 49,568,043–49,568,137, 95 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.6 kb of the gene's 64.3 kb; 1,503 of those bases code for the protein.

Traits linked to PTGIS

The Human Phenotype Ontology lists these as features of the rare conditions PTGIS can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). PTGIS gene: prostaglandin I2 synthase. Retrieved 17 October 2026, from https://dantelabs.com/genes/ptgis

Vancouver

Dante Labs. PTGIS gene: prostaglandin I2 synthase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ptgis

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