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Gene

MAP3K8

mitogen-activated protein kinase kinase kinase 8

Summary

Cytogenetic location
10p11.23
Coordinates
Chromosome 10: 30,434,184–30,461,833 (GRCh38)
Exons
9 exons across 27.7 kb
Protein
467 amino acids
Also known as
Tpl-2, EST, c-COT, MEKK8
Previous symbols
COT, ESTF
MANE Select transcript
ENST00000263056.6NM_005204.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MAP3K8 yet. The test sequences your whole genome, so your data includes it all the same.

How MAP3K8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 10, with a bracket where MAP3K8 sits. MAP3K8 and 4 genes near it on chromosome 10, from 29,948,009 to 30,948,008.Chromosome 1010p11.23p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.330 Mb30.2 Mb30.4 Mb30.6 Mb30.8 MbJCAD: 30,012,803–30,115,494, reverse strandJCADMTPAP: 30,309,801–30,374,448, reverse strandMTPAPMAP3K8: 30,434,184–30,461,833, forward strandMAP3K8LYZL2: 30,606,221–30,629,762, reverse strandLYZL2ZNF438: 30,820,207–31,032,110, reverse strandZNF438Diagram of MAP3K8: 9 exons on the forward strand of chromosome 10Exon 1: 30,434,184–30,434,378, 195 basesExon 2: 30,437,176–30,437,406, 231 basesExon 3: 30,438,916–30,439,274, 359 basesExon 4: 30,447,782–30,447,949, 168 basesExon 5: 30,450,258–30,450,519, 262 basesExon 6: 30,451,638–30,451,744, 107 basesExon 7: 30,458,084–30,458,236, 153 basesExon 8: 30,459,255–30,459,501, 247 basesExon 9: 30,460,706–30,461,833, 1,128 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 27.7 kb; 1,404 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). MAP3K8 gene: mitogen-activated protein kinase kinase kinase 8. Retrieved 17 October 2026, from https://dantelabs.com/genes/map3k8

Vancouver

Dante Labs. MAP3K8 gene: mitogen-activated protein kinase kinase kinase 8 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/map3k8

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