Traits

Traits linked to IRF3

interferon regulatory factor 3

The Human Phenotype Ontology links 5 traits to IRF3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
CSF lymphocytic pleiocytosis	Always
Epilepsy	Often (30–79%)
Headache	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Nuchal rigidity	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
HSV encephalitis	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IRF3 and how often each is seen. Find out more at hpo.jax.org.

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