Traits

Traits linked to GCGR

glucagon receptor

The Human Phenotype Ontology links 15 traits to GCGR, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the digestive system

Trait	How often it is seen
Pancreatic alpha-cell hyperplasia	Always
Abdominal pain	Often (30–79%)
Abnormal biliary tract morphology	Often (30–79%)
Cancer of the pancreas	Often (30–79%)
Gallstones	Often (30–79%)
Recurring pancreas inflammation	Often (30–79%)
Zollinger-Ellison syndrome	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Palpitations	Always
Necrolytic migratory erythema	Not recorded

Abnormality of the endocrine system

Trait	How often it is seen
Increased glucagon level	Always
Glucagonoma	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Noninsulin-dependent diabetes	Often (30–79%)
Diabetes mellitus	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Inflammation of the mouth	Not recorded

Abnormality of the ear

Trait	How often it is seen
Dizziness	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GCGR and how often each is seen. Find out more at hpo.jax.org.

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