CFTR c.1680-877G>T (rs397508261)

Dante Labs

Variant

CFTR c.1680-877G>T

NM_000492.4(CFTR):c.1680-877G>T (p.?)

Also known as

p.=
p.?
rs397508261

ClinVar classification: Pathogenic
Review status: 3 stars out of 4reviewed by expert panel
Last evaluated: 17 March 2017
Expert panel: CFTR2

Data current to ClinVar release 2026-10-12 · Dante Labs data release 2026.10.16-c6eea6bfFacts last changed 16 October 2026

Reference genomeGRCh38hg38

Positions on gene and variant pages follow this choice, in this browser.

Summary

c.1680-877G>T is a variant in CFTR. ClinVar classifies it as pathogenic for Cystic Fibrosis (reviewed by expert panel).

ClinVar classifications

Condition	Classification	Review status	Submissions	Last evaluated
Cystic FibrosisClinVar VCV000053331 (opens in a new tab)	Pathogenic	3 stars out of 4reviewed by expert panel	1 submission	17 March 2017

Classifications as ClinVar records them in release 2026-10-12. ClinVar updates them as evidence is reviewed.

Where it lies in CFTR

c.1680-877G>T lies in intron 12, between exons 12 and 13 of the 27 in CFTR's MANE Select transcript, NM_000492.4.

CFTR's gene diagram →

Molecular details

Gene	CFTR
Transcript	NM_000492.4MANE Select
Coding DNA change (HGVS c.)	c.1680-877G>T
Protein change (HGVS p.)	p.?
Predicted consequence	Othercoding_transcript_intron_variant
Predicted impact	Modifier
Position (GRCh38)	chr7:117589476 G>T
Position (GRCh37)	chr7:117229530 G>T
dbSNP ID	rs397508261 (opens in a new tab)
ClinVar Variation ID	VCV000053331 (opens in a new tab)
ClinVar Allele ID	67999
ClinGen Allele Registry ID	CA326598 (opens in a new tab)
ClinVar name	NM_000492.4(CFTR):c.1680-877G>T
Other names	p.=

CFTR c.1680-877G>T in other databases

Reports that look at this variant (1)

These Genome Test condition reports include c.1680-877G>T among the variants they look at.

Report	Conditions	Inheritance
Cystic Fibrosis	Cystic Fibrosis	Autosomal recessive

All CFTR variants

Limitations

This page describes publicly available information about a genetic variant. It is not a diagnosis, and it says nothing about whether you or anyone else carries this variant.

Classifications come from ClinVar and change as new evidence is reviewed. A classification here may differ from the one in ClinVar today, or from the one a laboratory reports.

Whole genome sequencing with short reads can miss or miscall some variants, particularly in repeated or highly similar stretches of DNA and in large insertions, deletions or rearrangements.

If you have questions about a variant in your own results or in your family, talk to a genetic counsellor or your doctor.

Sources & credits

Classifications from ClinVar (release 2026-10-12), National Center for Biotechnology Information.
Condition terms from the Mondo Disease Ontology (release 2026-10-06), used under CC BY 4.0.
Gene symbols and names from the HUGO Gene Nomenclature Committee (release 2026-10-16).
Allele identifiers from the ClinGen Allele Registry (release 2026-10-16-c4908f54).
Reference SNP identifiers from dbSNP (release b157), National Center for Biotechnology Information.
Gene–disease links from the Gene Curation Coalition, GenCC (release 2026-10-16).
Difficult regions from the Genome in a Bottle Consortium (release v3.6).
Transcripts from MANE (release v1.5), NCBI and EMBL-EBI.
Predicted consequences from mehari (release 0.11.0), with transcript models from cdot.
Built from Dante Labs data release 2026.10.16-c6eea6bf of 16 October 2026.

Cite this page

APA

Dante Labs. (16 October 2026). CFTR c.1680-877G>T (rs397508261) (Version 2026.10.16-c6eea6bf). Retrieved 16 October 2026, from https://dantelabs.com/genes/cftr/variants/c-1680-877g-t

Vancouver

Dante Labs. CFTR c.1680-877G>T (rs397508261) [Internet]. Version 2026.10.16-c6eea6bf. 16 October 2026 [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cftr/variants/c-1680-877g-t

Download citationRIS BibTeX CSL-JSON

Read your whole genome

From $449Free shipping · Results in 6–8 weeks

Explore the Genome Test