Gene
CDKN1A
cyclin dependent kinase inhibitor 1A
- HGNC 1784↗(opens in a new tab)
- Ensembl gene ENSG00000124762↗(opens in a new tab)
- NCBI Gene 1026↗(opens in a new tab)
Summary
- Cytogenetic location
- 6p21.2
- Coordinates
- Chromosome 6: 36,678,714–36,687,332 (GRCh38)
- Exons
- 3 exons across 8.6 kb
- Protein
- 164 amino acids
- Also known as
- P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1, p21
- Previous symbols
- CDKN1
- MANE Select transcript
- ENST00000244741.10NM_000389.5
- Locus type
- Protein-coding
- Very high
- Confident
- Low
- Very low
This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
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page <- fromJSON(url)
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How CDKN1A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.1 kb of the gene's 8.6 kb; 495 of those bases code for the protein.
Sequencing CDKN1A
2Low
How hard CDKN1A is to sequence with short reads, out of 100Each bar is the share of CDKN1A's exon bases in that kind of difficult region. The score weighs them by how much each costs a short-read call: 0 when no base is in any, 100 when every base is in all of them.
- MappabilityStretches where 100 or 250 bp reads cannot be placed uniquely, so a call there may be missing or wrong. Weight 35%.0%
- HomologySegmental duplications: copies elsewhere in the genome, such as paralogues and pseudogenes, at 90% identity or more. Weight 30%.0%
- RepeatsTandem repeats and runs of one base, which reads slip on and may not span. Weight 15%.1%
- GC contentWindows under 25% or over 65% G and C, which library preparation covers thinly. Weight 10%.21%
- Reference coverageGaps in the reference assembly nearby, where there is no sequence for reads to align to. Weight 10%.0%
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
Cite this page
Dante Labs. (n.d.). CDKN1A gene: cyclin dependent kinase inhibitor 1A. Retrieved 18 October 2026, from https://dantelabs.com/genes/cdkn1a
Dante Labs. CDKN1A gene: cyclin dependent kinase inhibitor 1A [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/cdkn1a
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