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Gene

ARHGEF12

Rho guanine nucleotide exchange factor 12

Summary

Cytogenetic location
11q23.3
Coordinates
Chromosome 11: 120,336,413–120,489,937 (GRCh38)
Exons
41 exons across 153.5 kb
Protein
1,544 amino acids
Also known as
KIAA0382, LARG
MANE Select transcript
ENST00000397843.7NM_015313.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads ARHGEF12 yet. The test sequences your whole genome, so your data includes it all the same.

How ARHGEF12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where ARHGEF12 sits. ARHGEF12 and 5 genes near it on chromosome 11, from 119,913,175 to 120,913,174.Chromosome 1111q23.3p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q25120 Mb120.2 Mb120.4 Mb120.6 Mb120.8 MbTRIM29: 120,111,286–120,185,529, reverse strandTRIM29OAF: 120,210,728–120,231,205, forward strandOAFPOU2F3: 120,236,640–120,320,040, forward strandPOU2F3TLCD5: 120,325,180–120,335,122, forward strandTLCD5ARHGEF12: 120,336,413–120,489,937, forward strandARHGEF12GRIK4: 120,511,709–120,988,906, forward strandGRIK4Diagram of ARHGEF12: 41 exons on the forward strand of chromosome 11Exon 1: 120,336,413–120,337,275, 863 basesExon 2: 120,406,118–120,406,141, 24 basesExon 3: 120,407,738–120,407,823, 86 basesExon 4: 120,409,394–120,409,450, 57 basesExon 5: 120,420,753–120,420,851, 99 basesExon 6: 120,421,803–120,421,852, 50 basesExon 7: 120,424,358–120,424,415, 58 basesExon 8: 120,428,069–120,428,247, 179 basesExon 9: 120,429,440–120,429,517, 78 basesExon 10: 120,429,712–120,429,831, 120 basesExon 11: 120,431,771–120,431,911, 141 basesExon 12: 120,437,308–120,437,382, 75 basesExon 13: 120,440,129–120,440,221, 93 basesExon 14: 120,441,707–120,441,817, 111 basesExon 15: 120,442,104–120,442,202, 99 basesExon 16: 120,445,422–120,445,464, 43 basesExon 17: 120,446,403–120,446,508, 106 basesExon 18: 120,446,948–120,447,085, 138 basesExon 19: 120,447,874–120,447,906, 33 basesExon 20: 120,448,234–120,448,348, 115 basesExon 21: 120,449,109–120,449,214, 106 basesExon 22: 120,451,512–120,451,724, 213 basesExon 23: 120,457,118–120,457,250, 133 basesExon 24: 120,457,721–120,457,756, 36 basesExon 25: 120,458,080–120,458,234, 155 basesExon 26: 120,459,174–120,459,320, 147 basesExon 27: 120,460,672–120,460,757, 86 basesExon 28: 120,465,237–120,465,362, 126 basesExon 29: 120,467,194–120,467,308, 115 basesExon 30: 120,469,288–120,469,388, 101 basesExon 31: 120,473,050–120,473,127, 78 basesExon 32: 120,474,560–120,474,635, 76 basesExon 33: 120,475,340–120,475,507, 168 basesExon 34: 120,476,661–120,476,748, 88 basesExon 35: 120,477,219–120,477,305, 87 basesExon 36: 120,477,447–120,477,526, 80 basesExon 37: 120,478,156–120,478,389, 234 basesExon 38: 120,479,960–120,480,430, 471 basesExon 39: 120,481,260–120,481,576, 317 basesExon 40: 120,484,438–120,484,507, 70 basesExon 41: 120,485,067–120,489,937, 4,871 bases125415′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.3 kb of the gene's 153.5 kb; 4,635 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). ARHGEF12 gene: Rho guanine nucleotide exchange factor 12. Retrieved 17 October 2026, from https://dantelabs.com/genes/arhgef12

Vancouver

Dante Labs. ARHGEF12 gene: Rho guanine nucleotide exchange factor 12 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/arhgef12

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