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Gene

APPL2

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2

Summary

Cytogenetic location
12q23.3
Coordinates
Chromosome 12: 105,173,300–105,236,174 (GRCh38)
Exons
21 exons across 62.9 kb
Protein
664 amino acids
Also known as
FLJ10659, DIP13B
MANE Select transcript
ENST00000258530.8NM_018171.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads APPL2 yet. The test sequences your whole genome, so your data includes it all the same.

How APPL2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where APPL2 sits. APPL2 and 6 genes near it on chromosome 12, from 104,704,737 to 105,704,736.Chromosome 1212q23.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33104.8 Mb105 Mb105.2 Mb105.4 Mb105.6 MbCHST11: 104,455,295–104,762,014, forward strandCHST11SLC41A2: 104,801,801–104,958,759, reverse strandSLC41A2NOPCHAP1: 104,986,296–105,074,197, forward strandNOPCHAP1ALDH1L2: 105,019,784–105,107,643, reverse strandALDH1L2WASHC4: 105,107,324–105,169,401, forward strandWASHC4APPL2: 105,173,300–105,236,174, reverse strandAPPL2C12orf75: 105,235,290–105,412,882, forward strandC12orf75Diagram of APPL2: 21 exons on the reverse strand of chromosome 12Exon 21: 105,173,300–105,174,448, 1,149 basesExon 20: 105,176,035–105,176,082, 48 basesExon 19: 105,176,876–105,177,016, 141 basesExon 18: 105,177,226–105,177,262, 37 basesExon 17: 105,188,273–105,188,447, 175 basesExon 16: 105,189,772–105,189,824, 53 basesExon 15: 105,189,991–105,190,155, 165 basesExon 14: 105,195,261–105,195,349, 89 basesExon 13: 105,195,445–105,195,501, 57 basesExon 12: 105,195,585–105,195,627, 43 basesExon 11: 105,197,765–105,197,953, 189 basesExon 10: 105,199,373–105,199,531, 159 basesExon 9: 105,203,703–105,203,785, 83 basesExon 8: 105,207,061–105,207,207, 147 basesExon 7: 105,207,971–105,208,029, 59 basesExon 6: 105,208,158–105,208,199, 42 basesExon 5: 105,211,230–105,211,317, 88 basesExon 4: 105,217,069–105,217,140, 72 basesExon 3: 105,217,666–105,217,725, 60 basesExon 2: 105,229,125–105,229,223, 99 basesExon 1: 105,235,959–105,236,174, 216 bases21201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.2 kb of the gene's 62.9 kb; 1,995 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). APPL2 gene: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/appl2

Vancouver

Dante Labs. APPL2 gene: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/appl2

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