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Gene

APAF1

apoptotic peptidase activating factor 1

Summary

Cytogenetic location
12q23.1
Coordinates
Chromosome 12: 98,645,290–98,735,433 (GRCh38)
Exons
27 exons across 90.1 kb
Protein
1,248 amino acids
Also known as
CED4, APAF-1
MANE Select transcript
ENST00000551964.6NM_181861.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads APAF1 yet. The test sequences your whole genome, so your data includes it all the same.

How APAF1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where APAF1 sits. APAF1 and 4 genes near it on chromosome 12, from 98,190,362 to 99,190,361.Chromosome 1212q23.1p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3398.2 Mb98.4 Mb98.6 Mb98.8 Mb99 MbTMPO: 98,515,483–98,550,351, forward strandTMPOSLC25A3: 98,574,411–98,606,379, forward strandSLC25A3IKBIP: 98,613,405–98,645,113, reverse strandIKBIPAPAF1: 98,645,290–98,735,433, forward strandAPAF1ANKS1B: 98,726,457–99,984,964, reverse strandANKS1BDiagram of APAF1: 27 exons on the forward strand of chromosome 12Exon 1: 98,645,290–98,645,835, 546 basesExon 2: 98,648,319–98,648,497, 179 basesExon 3: 98,648,626–98,648,815, 190 basesExon 4: 98,649,487–98,649,684, 198 basesExon 5: 98,659,160–98,659,343, 184 basesExon 6: 98,662,456–98,662,568, 113 basesExon 7: 98,662,675–98,662,806, 132 basesExon 8: 98,665,553–98,665,791, 239 basesExon 9: 98,666,190–98,666,357, 168 basesExon 10: 98,667,513–98,667,644, 132 basesExon 11: 98,670,973–98,671,086, 114 basesExon 12: 98,671,535–98,671,719, 185 basesExon 13: 98,677,425–98,677,551, 127 basesExon 14: 98,680,277–98,680,402, 126 basesExon 15: 98,683,143–98,683,274, 132 basesExon 16: 98,686,748–98,686,873, 126 basesExon 17: 98,699,408–98,699,569, 162 basesExon 18: 98,703,371–98,703,499, 129 basesExon 19: 98,706,485–98,706,610, 126 basesExon 20: 98,708,585–98,708,704, 120 basesExon 21: 98,712,319–98,712,435, 117 basesExon 22: 98,715,427–98,715,552, 126 basesExon 23: 98,723,193–98,723,312, 120 basesExon 24: 98,723,639–98,723,764, 126 basesExon 25: 98,725,415–98,725,540, 126 basesExon 26: 98,727,173–98,727,316, 144 basesExon 27: 98,732,420–98,735,433, 3,014 bases1510152025275′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.2 kb of the gene's 90.1 kb; 3,747 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.

Cite this page

APA

Dante Labs. (n.d.). APAF1 gene: apoptotic peptidase activating factor 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/apaf1

Vancouver

Dante Labs. APAF1 gene: apoptotic peptidase activating factor 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/apaf1

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