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Condition report · Endocrine

Graves' Disease

An autoimmune disorder causing hyperthyroidism due to an overactive thyroid gland, often characterized by goiter and ophthalmopathy.

A condition report looks for rare variants known to cause the conditions it covers.

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The 5 conditions we analyse

Thyrotoxicosis

A hypermetabolic syndrome caused by the elevation of thyroid hormone levels in the serum. Signs and symptoms include tachycardia, palpitations, tremor, weight loss, warm weather intolerance, and moist skin. Causes include Graves disease, toxic nodular goiter, toxic thyroid nodule, and lymphocytic thyroiditis.

Also known as

Graves disease, susceptibility to, 1; GRD1

Specific forms also covered

  • Neonatal Thyrotoxicosis

    A hypermetabolic syndrome characterized by tachycardia, palpitations, tremor, weight loss, and moist skin that is caused by the elevation of thyroid hormone levels in the serum of the newborn infant or thyroid-axis receptor activation, most commonly due to transplacental passage of thyroid stimulating globulins.

Includes 1 related subtype ↓
  • neonatal thyrotoxicosis
MONDO:0010138MedGen 11814

Toxic Diffuse Goiter

Specific forms also covered

  • Graves Disease

    Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism).It is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. Graves disease is the most common cause of hyperthyroidism andoccurs mostoften in women over age 20. However, the disorder may occur at any age and may affect males as well.Treatmentmayinclude radioiodine therapy, antithyroid drugs, and/or thyroid surgery.

  • Pediatric-Onset Graves Disease

Includes 2 related subtypes ↓
  • Graves disease
  • pediatric-onset Graves disease
MONDO:0001104MedGen 488851

Other endocrine conditions

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