Introduction
As we commemorate World Obesity Day, we want to take time to reflect on the complexities of obesity and the vital role that genetic testing plays in understanding and preventing this pervasive health issue. Obesity goes beyond mere aesthetics, posing serious medical risks such as heart disease, diabetes, high blood pressure, and cancer. Today, we explore how cutting-edge technologies like Whole Genome Sequencing and the Dante Obesity Panel can revolutionize our approach to combating obesity and related metabolic disorders.
The Complexities of Obesity: Beyond the Surface
Obesity is one of the world's largest health problems, one that has shifted from being a problem in rich countries to a health challenge around the world. Obesity is more than excess body fat; it is a multifaceted medical problem with profound implications for overall health: is a risk factor for several of the world's leading causes of death, including heart disease, stroke, diabetes, and various types of cancer.
- 38% of the global population are currently either overweight or obese having a body mass index (BMI) higher than 25 kg/m2.
- By 2035, the global overweight and obesity prevalence is projected to reach 51%
- In the United States, 1 in 3 adult Americans is obese.
- Obese children under 5 years are estimated to be close to 39 million.
- A two- to threefold increase in the prevalence of overweight and obesity in school-age children has been reported in several developed regions of the world.
- One of the most affected European countries is Greece.
Genetics and Obesity
Although changes in the environment have undoubtedly driven the rapid increase in prevalence, obesity results from an interaction between environmental and innate biological factors. Genetic and epigenetic variations contribute to obesity by influencing the function of metabolic pathways in the body and regulating neural pathways and appetite centers. Subsequently, these variations influence insulin resistance, dyslipidemia, inflammation, hypertension, and ectopic fat deposition-especially in the liver, which are the markers of obesity. Twin, family and adoption studies have estimated the heritability of obesity to be between 40% and 70%. New advances in genetic testing have led to the identification of obesity-related genes.
The Power of Genetic Testing: Unraveling the Code of Health
Whole Genome Sequencing Analysis emerges as a cutting-edge technology that holds immense potential to unravel the mysteries of obesity. This advanced test delves deep into an individual's entire genome, leaving no genetic variant unexplored. By meticulously scanning the genetic landscape, this test identifies even the most elusive genetic variants associated with obesity, offering a comprehensive view of an individual's genetic makeup, informing on disease risk and severity, as well as lifestyle modifications and preventative measures. Testing can also provide motivation and guidance for behavior change and weight management strategies.
Dante Obesity Panel
Obesity panel is used to identify genetic variants associated with obesity and related metabolic disorders, such as type 2 diabetes and cardiovascular disease. This panel tests for genetic variants that are known to affect appetite regulation, energy expenditure, and lipid metabolism.
This panel is designed for individuals who are interested in understanding their genetic risk for obesity and related metabolic disorders.
- Based on Whole Genome Sequencing
- More than 45 genes analyzed
- Investigates SNP and Indel mutations up to 150 bp
List of main conditions:
- Obesity due to CEP19 deficiency
- Abdominal Obesity-Metabolic Syndrome
- Obesity due to leptin receptor gene deficiency
- Obesity due to prohormone convertase I deficiency
Conclusion
On World Obesity Day, let's harness the potential of genetic testing to shape a healthier future. Leveraging insights from Whole Genome Sequencing and the Dante Obesity Panel, individuals can make informed choices, embrace lifestyle changes, and progress towards improved well-being. Together, we can advocate for proactive health initiatives, raise awareness about the importance of genetic testing in combating obesity, and promote a culture of empowerment and wellness.
