Focal Segmental Glomerulosclerosis and Complement Genetic Study Report
Focal Segmental Glucerulosclerosis and Complement Genetic Study
Focal segmental glomerulosclerosis consists of a sclerosis process affecting the renal glomeruli. The underlying genetic mutations compromise the functionality of the podocytes, responsible for the synthesis of many components of the glomerular basement membrane. The complement system, part of innate immunity, may contribute to tubular injury.
more than 30 genes analyzed
It is recommended if:
Hemolytic Uremic Syndrome and Autosomal Dominant Interstitial Nephritis are two medical conditions affecting the excretory system. The first has an infectious origin but there are atypical, rarer forms whose onset is genetic in nature. The second involves, however, a picture of progressive renal failure, tubulointerstitial nephropathy and bland urinary sediment, in absence of glomerular lesions. Its etiology is exclusively genetic.
List of main conditions:
- Glomerulosclerosis, focal segmental, 1
- Nephrotic syndrome, type 3
- Nephrotic syndrome, type 9
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