The antibiotic that doesn't work, the pain medication that's ineffective — not because the drugs are wrong, but because your genes are processing them at a different speed than the dose imagined.
Whole genome sequencing identifies your CYP450 metabolizer phenotype, enabling physicians to select and dose medications that will work safely and effectively for your unique genetic makeup.
Pharmacogenomics — Drug Response
The cytochrome P450 family of drug-metabolizing enzymes are responsible for metabolizing more than 75% of all approved medications. Three genes — CYP3A4, CYP2D6, and CYP2C19 — are particularly important: CYP3A4 metabolizes approximately 50% of all drugs on the market, while CYP2D6 and CYP2C19 together metabolize another ~40%. These enzymes catalyze oxidation reactions that activate or inactivate drugs for excretion. Genetic variation in these genes creates four metabolizer phenotypes: poor metabolizers (PM) with very low enzyme activity, intermediate metabolizers (IM) with reduced activity, normal/extensive metabolizers (NM/EM, the wild-type), and ultra-rapid metabolizers (UM) with increased enzyme activity due to gene duplication or other structural variants.
CYP2D6 has 962 identified variants catalogued in the PharmGKB database, with complex structural variations including gene deletions (producing PM phenotype), duplications and multi-duplications (producing UM phenotype), and hybrid genes (producing variable function). CYP2C19 has 753 variants, predominantly affecting splicing, translation, and amino acid substitutions. CYP3A4 has 609 known variants. Loss-of-function variants produce low-activity phenotypes; gene duplications produce ultra-rapid metabolizers. The metabolizer phenotypes have profound clinical consequences: poor metabolizers may accumulate toxic drug levels on standard doses, while ultra-rapid metabolizers may achieve subtherapeutic concentrations.
Metabolizer phenotype determines safe and effective drug dosing across dozens of medication classes. Codeine, a prodrug activated by CYP2D6, provides no analgesia in poor metabolizers — they cannot convert codeine to its active metabolite morphine. Tricyclic antidepressants and antipsychotics accumulate to toxic levels in CYP2D6 poor metabolizers. CYP2C19 poor metabolizers cannot adequately activate clopidogrel (Plavix), reducing its antiplatelet effect and increasing stent thrombosis risk. Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes peer-reviewed dosing recommendations for >300 drug-gene pairs, guiding healthcare providers in optimizing medication selection and dosing.
Standard panels test 10-30 'star alleles' per gene. They miss novel and rare variants, particularly in under-represented populations.
Standard panels miss rare variants and structural variations
Standard pharmacogenomics panels test only 10-30 'star alleles' (haplotypes) per gene — pre-defined combinations of common variants. This approach captures the most common variants in most populations but misses novel or rare variants, particularly in under-represented populations. CYP2D6 poses particular challenges: copy number variation (CNVs — deletions and duplications) cannot be reliably detected by standard sequencing alone; specialized copy number detection methods are required. A patient may carry rare novel variants not represented on a standard panel, producing incorrect metabolizer phenotype prediction. Whole genome sequencing with copy number analysis provides comprehensive variant detection, allowing phenotype calculation from all detected variants rather than only pre-defined haplotypes.
Your drug doses must match your genetic metabolism profile
CYP2D6 poor metabolizer phenotype: codeine provides no pain relief; tramadol is ineffective; some antipsychotics and antidepressants accumulate to toxic levels requiring dose reduction. CYP2C19 poor metabolizers: clopidogrel (Plavix) activation is impaired, reducing antiplatelet effect and increasing stent thrombosis risk post-PCI; alternative P2Y12 inhibitors (prasugrel, ticagrelor) are preferred. CYP3A4 ultra-rapid metabolizers may require higher doses of many substrates. Phenotype results documented in the medical record and integrated into EHRs guide future prescribing, preventing dosing errors that cause therapeutic failure or life-threatening toxicity.
Your full DNA (not just a part of it)
Traditional genetic testing looks at narrow sets of genes, missing most parts of your genome. We sequence your full genome — every gene and every region between genes.
Comprehensive insights and specialized reports
Easy to read and with answers you and your doctor can act on. Not a file to interpret — 200+ clinical reports, organized by category.
Your test becomes more valuable every year
Your DNA does not change, but genome science is accelerating. Every month, new variant-disease associations are discovered. We validate these findings and update your reports automatically. Your test becomes more valuable every year.
The results doctors bring to their hardest cases.
Forty years of uncertainty. One test.
A patient had spent decades in the UK healthcare system without a diagnosis. Dante data, accepted by NHS clinical teams at Queen Elizabeth University Hospital Glasgow, identified Noonan Syndrome and a RUNX1 leukemia-associated variant that had gone undetected. After 40 years, they finally had an answer.
A complete read delivers a complete picture.
A patient came to Dante to investigate periodic paralysis. Reading the complete genome identified a concurrent hereditary cardiac finding — Brugada syndrome — that their doctor confirmed with an ECG. The result also explained a family member's unresolved cardiac history. One test. Every answer in it.
Sequenced in 2019. The data worked in 2021.
Jennifer sequenced her genome with Dante two years before her breast cancer diagnosis. When treatment began, Dante's pharmacogenomics data showed her prescribed chemotherapy would cause serious adverse effects. Her doctor selected an alternative — and she started effective treatment from day one.
Every genetic question deserves a complete answer.
Whether you are searching for answers today or protecting your health for tomorrow, a complete read of your entire genome is the only place to start.
It runs in your family. Now you can know if it runs in your genes.
Your genome contains inherited variants associated with medical conditions like cardiac, cancer, and neurological. We read all of them — with the clinical depth to give the result meaning.
Learn more →When traditional lab tests say you're fine. And you know you're not.
Standard diagnostic tests check for a pre-selected set of answers. We sequence your full DNA — including parts that no test was designed to check. If the answer is in your genome, we will help you find it.
Learn more →Your diagnosis may be right. Your treatment plan may be incomplete.
Your genes determine which treatments are most likely to work — and which are not. We give your doctor the tools and insights to inform your treatment plan.
Learn more →You want to know before something forces the question.
Some people don't wait for a diagnosis or a family history to act. Whole genome sequencing gives you the complete genetic picture now — so you and your doctor can make informed decisions before anything becomes urgent.
Learn more →You already took a DNA test. Here's what it couldn't tell you.
Most consumer DNA tests read less than 0.1% of your genome. We read all of it.
Learn more →Clinical-grade results. Chosen by individuals, trusted by doctors for their most complex cases.
Dante Genome Test helped specialists at a UK national acute hospital in the identification of Noonan Syndrome and a rare leukemia-associated genetic variant that had gone undetected. That result changed the medical care of the patient.
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Common questions about whole genome sequencing.
What is the difference between whole genome sequencing and a targeted genetic test?
Targeted genetic tests — including standard hereditary cancer panels — read a pre-defined list of known variants in a specific set of genes. They are designed to find what they already know to look for. Whole genome sequencing reads your entire genome: all 6 billion base pairs, every gene, every region between genes. A Mayo Clinic study published in JAMA Oncology found that standard testing guidelines missed more than half of patients with inherited cancer mutations. Genome Test does not have a fixed list.
What will I receive when my results are ready?
Your Dante Genome delivers 200+ physician-ready reports organized by clinical category — hereditary cancer, cardiac conditions, rare diseases, pharmacogenomics, carrier status, and more. Reports are delivered to your secure Genome Manager and are formatted for direct clinical use. Your genome data is permanently retained and re-analyzed automatically as science advances.
What happens if a clinically significant variant is found?
If a pathogenic or likely-pathogenic variant is identified, it will be clearly flagged in your physician-ready report with clinical context, published evidence, and recommended next steps. We recommend sharing any clinically significant finding with your physician or a genetic counselor, who can guide decisions about surveillance, risk reduction, or cascade testing for family members.
How is this different from a consumer DNA test like 23andMe or AncestryDNA?
Consumer DNA tests use genotyping chips that read less than 0.1% of your genome — a tiny pre-selected set of common variants. They are optimized for ancestry and population-level traits, not clinical genetic findings. The Dante Genome Test sequences 100% of your genome at 30X coverage, the same standard used in clinical diagnostic settings. The two tests are not comparable in scope, methodology, or clinical utility.
How long does it take to get results, and how are they delivered?
Your collection kit ships within 48 hours of ordering. Once your sample arrives at our CLIA-certified laboratory, sequencing and analysis takes 6–8 weeks. Results are delivered securely to your Genome Manager, where you can access your reports, share them with your physician, and receive automatic updates as new findings are validated against your genome.
We work with patient advocacy groups worldwide.
Dante Labs works with patient advocacy groups of any size — for Pharmacogenomics — Drug Response and other conditions, rare and common. We support groups in any country, including virtual patient advocacy groups.
We can provide customized reports, group discounts, and packages tailored for your members. Please reach out using the form and we'll be in touch within two business days.
- Custom genomic reports for your members
- Group discounts and tailored packages
- Any country — including virtual groups
- Rare and common conditions covered
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We’ll be in touch within 2 business days. To follow up directly: hello@dantelabs.com
One test.
A lifetime of answers.
One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. 200+ physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.
Ships within 48 hours · Results in 6–8 weeks
