You tested negative for BRCA. Your family kept getting breast cancer. The missing answer was a different gene entirely.
Whole genome sequencing identifies CHEK2 variants that explained the hereditary pattern in families previously labeled BRCA-negative — and opens pathways to enhanced screening.
CHEK2 (Hereditary Cancer Risk)
CHEK2 encodes checkpoint kinase 2, a serine/threonine kinase activated by ATM in response to DNA damage. Once activated, CHEK2 phosphorylates critical cell cycle regulators including p53 and BRCA1, coordinating DNA repair, cell cycle arrest, and apoptosis. Pathogenic CHEK2 variants impair this checkpoint function, allowing damaged cells to continue dividing unchecked. The most studied variant, c.1100delC, produces a truncated, unstable protein. Pathogenic CHEK2 variants are classified as moderate-penetrance — conferring approximately 2–3-fold increased breast cancer risk (lifetime risk ~20–30%), with risk stratified by family history.
CHEK2 is more common in the population than BRCA1/2 — the c.1100delC variant has a carrier frequency of 0.2–1.4% in European populations. Beyond breast cancer, CHEK2 variants are associated with modestly increased risk of prostate, colorectal, kidney, thyroid, and hematological cancers. Biallelic CHEK2 carriers (rare) have substantially higher breast cancer risk than monoallelic carriers. The challenge is that clinical guidelines for CHEK2 management are less established than for BRCA1/2, historically creating provider uncertainty.
A CHEK2 pathogenic variant finding has immediate clinical implications. It explains the hereditary breast cancer pattern in families that tested BRCA-negative — a finding that occurs in approximately 5% of such families. It qualifies carriers for enhanced breast MRI surveillance starting at age 40 (or earlier with family history). For males, it enables prostate cancer awareness and early screening discussion. Cascade testing of first-degree relatives identifies additional carriers who benefit from surveillance, converting one person's genetic discovery into family-wide preventive opportunities.
Single-gene BRCA testing and many panels omit CHEK2 entirely. Among women with breast cancer, 1.7% carry CHEK2 variants that standard testing misses.
CHEK2 is absent from BRCA-only and many standard panels
Many hereditary cancer panels were originally designed around BRCA1/2 and Lynch Syndrome genes. CHEK2, ATM, and PALB2 were added later, and not all panels include them. A landmark study showed that 76% of CHEK2 carriers would not qualify for enhanced surveillance under standard BRCA-only testing criteria. Among women with breast cancer undergoing multigene testing, approximately 1.7% carry pathogenic CHEK2 variants. Whole genome sequencing captures all hereditary cancer genes simultaneously, ensuring no variants slip through criteria-based gaps.
A CHEK2 finding clarifies previously unexplained cancer patterns
When a BRCA test is negative but family history remains strong, CHEK2 is often the explanation — a discovery that occurs in 5% of such families. Identifying a CHEK2 variant enables enhanced breast MRI surveillance from age 40, colorectal screening awareness, and prostate cancer monitoring for male carriers. It triggers cascade testing of relatives who may carry the same variant unknowingly. For some families, a CHEK2 finding finally provides the genetic explanation that had been missing.
Your full DNA (not just a part of it)
Traditional genetic testing looks at narrow sets of genes, missing most parts of your genome. We sequence your full genome — every gene and every region between genes.
Comprehensive insights and specialized reports
Easy to read and with answers you and your doctor can act on. Not a file to interpret — 200+ clinical reports, organized by category.
Your test becomes more valuable every year
Your DNA does not change, but genome science is accelerating. Every month, new variant-disease associations are discovered. We validate these findings and update your reports automatically. Your test becomes more valuable every year.
The results doctors bring to their hardest cases.
Forty years of uncertainty. One test.
A patient had spent decades in the UK healthcare system without a diagnosis. Dante data, accepted by NHS clinical teams at Queen Elizabeth University Hospital Glasgow, identified Noonan Syndrome and a RUNX1 leukemia-associated variant that had gone undetected. After 40 years, they finally had an answer.
A complete read delivers a complete picture.
A patient came to Dante to investigate periodic paralysis. Reading the complete genome identified a concurrent hereditary cardiac finding — Brugada syndrome — that their doctor confirmed with an ECG. The result also explained a family member's unresolved cardiac history. One test. Every answer in it.
Sequenced in 2019. The data worked in 2021.
Jennifer sequenced her genome with Dante two years before her breast cancer diagnosis. When treatment began, Dante's pharmacogenomics data showed her prescribed chemotherapy would cause serious adverse effects. Her doctor selected an alternative — and she started effective treatment from day one.
Every genetic question deserves a complete answer.
Whether you are searching for answers today or protecting your health for tomorrow, a complete read of your entire genome is the only place to start.
It runs in your family. Now you can know if it runs in your genes.
Your genome contains inherited variants associated with medical conditions like cardiac, cancer, and neurological. We read all of them — with the clinical depth to give the result meaning.
Learn more →When traditional lab tests say you're fine. And you know you're not.
Standard diagnostic tests check for a pre-selected set of answers. We sequence your full DNA — including parts that no test was designed to check. If the answer is in your genome, we will help you find it.
Learn more →Your diagnosis may be right. Your treatment plan may be incomplete.
Your genes determine which treatments are most likely to work — and which are not. We give your doctor the tools and insights to inform your treatment plan.
Learn more →You want to know before something forces the question.
Some people don't wait for a diagnosis or a family history to act. Whole genome sequencing gives you the complete genetic picture now — so you and your doctor can make informed decisions before anything becomes urgent.
Learn more →You already took a DNA test. Here's what it couldn't tell you.
Most consumer DNA tests read less than 0.1% of your genome. We read all of it.
Learn more →Clinical-grade results. Chosen by individuals, trusted by doctors for their most complex cases.
Dante Genome Test helped specialists at a UK national acute hospital in the identification of Noonan Syndrome and a rare leukemia-associated genetic variant that had gone undetected. That result changed the medical care of the patient.
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Common questions about whole genome sequencing.
What is the difference between whole genome sequencing and a targeted genetic test?
Targeted genetic tests — including standard hereditary cancer panels — read a pre-defined list of known variants in a specific set of genes. They are designed to find what they already know to look for. Whole genome sequencing reads your entire genome: all 6 billion base pairs, every gene, every region between genes. A Mayo Clinic study published in JAMA Oncology found that standard testing guidelines missed more than half of patients with inherited cancer mutations. Genome Test does not have a fixed list.
What will I receive when my results are ready?
Your Dante Genome delivers 200+ physician-ready reports organized by clinical category — hereditary cancer, cardiac conditions, rare diseases, pharmacogenomics, carrier status, and more. Reports are delivered to your secure Genome Manager and are formatted for direct clinical use. Your genome data is permanently retained and re-analyzed automatically as science advances.
What happens if a clinically significant variant is found?
If a pathogenic or likely-pathogenic variant is identified, it will be clearly flagged in your physician-ready report with clinical context, published evidence, and recommended next steps. We recommend sharing any clinically significant finding with your physician or a genetic counselor, who can guide decisions about surveillance, risk reduction, or cascade testing for family members.
How is this different from a consumer DNA test like 23andMe or AncestryDNA?
Consumer DNA tests use genotyping chips that read less than 0.1% of your genome — a tiny pre-selected set of common variants. They are optimized for ancestry and population-level traits, not clinical genetic findings. The Dante Genome Test sequences 100% of your genome at 30X coverage, the same standard used in clinical diagnostic settings. The two tests are not comparable in scope, methodology, or clinical utility.
How long does it take to get results, and how are they delivered?
Your collection kit ships within 48 hours of ordering. Once your sample arrives at our CLIA-certified laboratory, sequencing and analysis takes 6–8 weeks. Results are delivered securely to your Genome Manager, where you can access your reports, share them with your physician, and receive automatic updates as new findings are validated against your genome.
We work with patient advocacy groups worldwide.
Dante Labs works with patient advocacy groups of any size — for CHEK2 (Hereditary Cancer Risk) and other conditions, rare and common. We support groups in any country, including virtual patient advocacy groups.
We can provide customized reports, group discounts, and packages tailored for your members. Please reach out using the form and we'll be in touch within two business days.
- Custom genomic reports for your members
- Group discounts and tailored packages
- Any country — including virtual groups
- Rare and common conditions covered
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One test.
A lifetime of answers.
One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. 200+ physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.
Ships within 48 hours · Results in 6–8 weeks
