{
  "url": "https://dantelabs.com/traits/widely-spaced-teeth",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "widely-spaced-teeth",
    "id": "HP:0000687",
    "name": "Widely spaced teeth",
    "definition": "Increased spaces (diastemata) between most of the teeth in the same dental arch.",
    "synonyms": [
      "Wide-spaced teeth",
      "Widely-spaced teeth",
      "Generalised dental spacing",
      "Generalised spacing of teeth",
      "Generalized dental spacing",
      "Generalized spacing of teeth",
      "Multiple diastemata"
    ],
    "systems": [
      {
        "slug": "abnormality-of-head-or-neck",
        "name": "Abnormality of head or neck",
        "url": "https://dantelabs.com/traits/abnormality-of-head-or-neck"
      }
    ],
    "broader": [
      {
        "slug": "tooth-malposition",
        "name": "Abnormal dental position",
        "url": "https://dantelabs.com/traits/tooth-malposition"
      }
    ],
    "narrower": [
      {
        "slug": "widely-spaced-primary-teeth",
        "name": "Wide gaps between baby teeth",
        "genes": 6,
        "url": "https://dantelabs.com/traits/widely-spaced-primary-teeth"
      }
    ],
    "genes": [
      {
        "slug": "cdk19",
        "symbol": "CDK19",
        "hgnc": "HGNC:19338",
        "name": "cyclin dependent kinase 19",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk19"
      },
      {
        "slug": "cdk5rap2",
        "symbol": "CDK5RAP2",
        "hgnc": "HGNC:18672",
        "name": "CDK5 regulatory subunit associated protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdk5rap2"
      },
      {
        "slug": "drg1",
        "symbol": "DRG1",
        "hgnc": "HGNC:3029",
        "name": "developmentally regulated GTP binding protein 1",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/drg1"
      },
      {
        "slug": "fgf3",
        "symbol": "FGF3",
        "hgnc": "HGNC:3681",
        "name": "fibroblast growth factor 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/fgf3"
      },
      {
        "slug": "gtpbp2",
        "symbol": "GTPBP2",
        "hgnc": "HGNC:4670",
        "name": "GTP binding protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gtpbp2"
      },
      {
        "slug": "ift140",
        "symbol": "IFT140",
        "hgnc": "HGNC:29077",
        "name": "intraflagellar transport 140",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ift140"
      },
      {
        "slug": "ift43",
        "symbol": "IFT43",
        "hgnc": "HGNC:29669",
        "name": "intraflagellar transport 43",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift43"
      },
      {
        "slug": "ift52",
        "symbol": "IFT52",
        "hgnc": "HGNC:15901",
        "name": "intraflagellar transport 52",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift52"
      },
      {
        "slug": "jkamp",
        "symbol": "JKAMP",
        "hgnc": "HGNC:20184",
        "name": "JNK1/MAPK8 associated membrane protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/jkamp"
      },
      {
        "slug": "kdm1a",
        "symbol": "KDM1A",
        "hgnc": "HGNC:29079",
        "name": "lysine demethylase 1A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kdm1a"
      },
      {
        "slug": "kiaa0753",
        "symbol": "KIAA0753",
        "hgnc": "HGNC:29110",
        "name": "KIAA0753",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kiaa0753"
      },
      {
        "slug": "med16",
        "symbol": "MED16",
        "hgnc": "HGNC:17556",
        "name": "mediator complex subunit 16",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med16"
      },
      {
        "slug": "piga",
        "symbol": "PIGA",
        "hgnc": "HGNC:8957",
        "name": "phosphatidylinositol glycan anchor biosynthesis class A",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/piga"
      },
      {
        "slug": "ppfia3",
        "symbol": "PPFIA3",
        "hgnc": "HGNC:9247",
        "name": "PPFI scaffold protein A3",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppfia3"
      },
      {
        "slug": "rdh11",
        "symbol": "RDH11",
        "hgnc": "HGNC:17964",
        "name": "retinol dehydrogenase 11",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rdh11"
      },
      {
        "slug": "smc3",
        "symbol": "SMC3",
        "hgnc": "HGNC:2468",
        "name": "structural maintenance of chromosomes 3",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smc3"
      },
      {
        "slug": "taf4",
        "symbol": "TAF4",
        "hgnc": "HGNC:11537",
        "name": "TATA-box binding protein associated factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/taf4"
      },
      {
        "slug": "tbl1xr1",
        "symbol": "TBL1XR1",
        "hgnc": "HGNC:29529",
        "name": "TBL1X/Y related 1",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbl1xr1"
      },
      {
        "slug": "tcf4",
        "symbol": "TCF4",
        "hgnc": "HGNC:11634",
        "name": "transcription factor 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tcf4"
      },
      {
        "slug": "wdr35",
        "symbol": "WDR35",
        "hgnc": "HGNC:29250",
        "name": "WD repeat domain 35",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wdr35"
      },
      {
        "slug": "brd4",
        "symbol": "BRD4",
        "hgnc": "HGNC:13575",
        "name": "bromodomain containing 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/brd4"
      },
      {
        "slug": "hdac4",
        "symbol": "HDAC4",
        "hgnc": "HGNC:14063",
        "name": "histone deacetylase 4",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hdac4"
      },
      {
        "slug": "hdac8",
        "symbol": "HDAC8",
        "hgnc": "HGNC:13315",
        "name": "histone deacetylase 8",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/hdac8"
      },
      {
        "slug": "larp7",
        "symbol": "LARP7",
        "hgnc": "HGNC:24912",
        "name": "La ribonucleoprotein 7, transcriptional regulator",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/larp7"
      },
      {
        "slug": "mau2",
        "symbol": "MAU2",
        "hgnc": "HGNC:29140",
        "name": "MAU2 sister chromatid cohesion factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/mau2"
      },
      {
        "slug": "nipbl",
        "symbol": "NIPBL",
        "hgnc": "HGNC:28862",
        "name": "NIPBL cohesin loading factor",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nipbl"
      },
      {
        "slug": "rad21",
        "symbol": "RAD21",
        "hgnc": "HGNC:9811",
        "name": "RAD21 cohesin complex component",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rad21"
      },
      {
        "slug": "rps6ka3",
        "symbol": "RPS6KA3",
        "hgnc": "HGNC:10432",
        "name": "ribosomal protein S6 kinase A3",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/rps6ka3"
      },
      {
        "slug": "smc1a",
        "symbol": "SMC1A",
        "hgnc": "HGNC:11111",
        "name": "structural maintenance of chromosomes 1A",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smc1a"
      },
      {
        "slug": "ssr4",
        "symbol": "SSR4",
        "hgnc": "HGNC:11326",
        "name": "signal sequence receptor subunit 4",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/ssr4"
      },
      {
        "slug": "wdr26",
        "symbol": "WDR26",
        "hgnc": "HGNC:21208",
        "name": "WD repeat domain 26",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/wdr26"
      },
      {
        "slug": "adnp",
        "symbol": "ADNP",
        "hgnc": "HGNC:15766",
        "name": "activity dependent neuroprotector homeobox",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/adnp"
      },
      {
        "slug": "aff3",
        "symbol": "AFF3",
        "hgnc": "HGNC:6473",
        "name": "ALF transcription elongation factor 3",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aff3"
      },
      {
        "slug": "ahdc1",
        "symbol": "AHDC1",
        "hgnc": "HGNC:25230",
        "name": "AT-hook DNA binding motif containing 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ahdc1"
      },
      {
        "slug": "aimp2",
        "symbol": "AIMP2",
        "hgnc": "HGNC:20609",
        "name": "aminoacyl tRNA synthetase complex interacting multifunctional protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aimp2"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "arsk",
        "symbol": "ARSK",
        "hgnc": "HGNC:25239",
        "name": "arylsulfatase family member K",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/arsk"
      },
      {
        "slug": "b3glct",
        "symbol": "B3GLCT",
        "hgnc": "HGNC:20207",
        "name": "beta 3-glucosyltransferase",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/b3glct"
      },
      {
        "slug": "cdh3",
        "symbol": "CDH3",
        "hgnc": "HGNC:1762",
        "name": "cadherin 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdh3"
      },
      {
        "slug": "cert1",
        "symbol": "CERT1",
        "hgnc": "HGNC:2205",
        "name": "ceramide transporter 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cert1"
      },
      {
        "slug": "clp1",
        "symbol": "CLP1",
        "hgnc": "HGNC:16999",
        "name": "cleavage factor polyribonucleotide kinase subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/clp1"
      },
      {
        "slug": "dlx3",
        "symbol": "DLX3",
        "hgnc": "HGNC:2916",
        "name": "distal-less homeobox 3",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dlx3"
      },
      {
        "slug": "dyrk1a",
        "symbol": "DYRK1A",
        "hgnc": "HGNC:3091",
        "name": "dual specificity tyrosine phosphorylation regulated kinase 1A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/dyrk1a"
      },
      {
        "slug": "eda",
        "symbol": "EDA",
        "hgnc": "HGNC:3157",
        "name": "ectodysplasin A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eda"
      },
      {
        "slug": "edaradd",
        "symbol": "EDARADD",
        "hgnc": "HGNC:14341",
        "name": "EDAR associated via death domain",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/edaradd"
      },
      {
        "slug": "fgf10",
        "symbol": "FGF10",
        "hgnc": "HGNC:3666",
        "name": "fibroblast growth factor 10",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgf10"
      },
      {
        "slug": "fgfr1",
        "symbol": "FGFR1",
        "hgnc": "HGNC:3688",
        "name": "fibroblast growth factor receptor 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fgfr1"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "grem2",
        "symbol": "GREM2",
        "hgnc": "HGNC:17655",
        "name": "gremlin 2, DAN family BMP antagonist",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/grem2"
      },
      {
        "slug": "gusb",
        "symbol": "GUSB",
        "hgnc": "HGNC:4696",
        "name": "glucuronidase beta",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gusb"
      },
      {
        "slug": "irf6",
        "symbol": "IRF6",
        "hgnc": "HGNC:6121",
        "name": "interferon regulatory factor 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/irf6"
      },
      {
        "slug": "kansl1",
        "symbol": "KANSL1",
        "hgnc": "HGNC:24565",
        "name": "KAT8 regulatory NSL complex subunit 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kansl1"
      },
      {
        "slug": "kdm6a",
        "symbol": "KDM6A",
        "hgnc": "HGNC:12637",
        "name": "lysine demethylase 6A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kdm6a"
      },
      {
        "slug": "kmt2d",
        "symbol": "KMT2D",
        "hgnc": "HGNC:7133",
        "name": "lysine methyltransferase 2D",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/kmt2d"
      },
      {
        "slug": "lrp6",
        "symbol": "LRP6",
        "hgnc": "HGNC:6698",
        "name": "LDL receptor related protein 6",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lrp6"
      },
      {
        "slug": "mbd5",
        "symbol": "MBD5",
        "hgnc": "HGNC:20444",
        "name": "methyl-CpG binding domain protein 5",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mbd5"
      },
      {
        "slug": "msx1",
        "symbol": "MSX1",
        "hgnc": "HGNC:7391",
        "name": "msh homeobox 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/msx1"
      },
      {
        "slug": "nono",
        "symbol": "NONO",
        "hgnc": "HGNC:7871",
        "name": "non-POU domain containing octamer binding",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nono"
      },
      {
        "slug": "oca2",
        "symbol": "OCA2",
        "hgnc": "HGNC:8101",
        "name": "OCA2 melanosomal transmembrane protein",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/oca2"
      },
      {
        "slug": "pacs2",
        "symbol": "PACS2",
        "hgnc": "HGNC:23794",
        "name": "phosphofurin acidic cluster sorting protein 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pacs2"
      },
      {
        "slug": "pax9",
        "symbol": "PAX9",
        "hgnc": "HGNC:8623",
        "name": "paired box 9",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pax9"
      },
      {
        "slug": "pigl",
        "symbol": "PIGL",
        "hgnc": "HGNC:8966",
        "name": "phosphatidylinositol glycan anchor biosynthesis class L",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigl"
      },
      {
        "slug": "prkd1",
        "symbol": "PRKD1",
        "hgnc": "HGNC:9407",
        "name": "protein kinase D1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prkd1"
      },
      {
        "slug": "prr12",
        "symbol": "PRR12",
        "hgnc": "HGNC:29217",
        "name": "proline rich 12",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prr12"
      },
      {
        "slug": "ptprf",
        "symbol": "PTPRF",
        "hgnc": "HGNC:9670",
        "name": "protein tyrosine phosphatase receptor type F",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ptprf"
      },
      {
        "slug": "rlim",
        "symbol": "RLIM",
        "hgnc": "HGNC:13429",
        "name": "ring finger protein, LIM domain interacting",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rlim"
      },
      {
        "slug": "rnu2-2",
        "symbol": "RNU2-2",
        "hgnc": "HGNC:10152",
        "name": "RNA, U2 small nuclear 2",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rnu2-2"
      },
      {
        "slug": "smarca2",
        "symbol": "SMARCA2",
        "hgnc": "HGNC:11098",
        "name": "SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/smarca2"
      },
      {
        "slug": "sumo1",
        "symbol": "SUMO1",
        "hgnc": "HGNC:12502",
        "name": "small ubiquitin like modifier 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sumo1"
      },
      {
        "slug": "tbcd",
        "symbol": "TBCD",
        "hgnc": "HGNC:11581",
        "name": "tubulin folding cofactor D",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/tbcd"
      },
      {
        "slug": "tgfa",
        "symbol": "TGFA",
        "hgnc": "HGNC:11765",
        "name": "transforming growth factor alpha",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tgfa"
      },
      {
        "slug": "ube3a",
        "symbol": "UBE3A",
        "hgnc": "HGNC:12496",
        "name": "ubiquitin protein ligase E3A",
        "frequency": "frequent",
        "diseases": 4,
        "url": "https://dantelabs.com/genes/ube3a"
      },
      {
        "slug": "wnt10a",
        "symbol": "WNT10A",
        "hgnc": "HGNC:13829",
        "name": "Wnt family member 10A",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10a"
      },
      {
        "slug": "wnt10b",
        "symbol": "WNT10B",
        "hgnc": "HGNC:12775",
        "name": "Wnt family member 10B",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wnt10b"
      },
      {
        "slug": "atp6v1b2",
        "symbol": "ATP6V1B2",
        "hgnc": "HGNC:854",
        "name": "ATPase H+ transporting V1 subunit B2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp6v1b2"
      },
      {
        "slug": "atxn7l3",
        "symbol": "ATXN7L3",
        "hgnc": "HGNC:25416",
        "name": "ataxin 7 like 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atxn7l3"
      },
      {
        "slug": "bap1",
        "symbol": "BAP1",
        "hgnc": "HGNC:950",
        "name": "BRCA1 associated deubiquitinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bap1"
      },
      {
        "slug": "bcas3",
        "symbol": "BCAS3",
        "hgnc": "HGNC:14347",
        "name": "BCAS3 microtubule associated cell migration factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcas3"
      },
      {
        "slug": "camk2b",
        "symbol": "CAMK2B",
        "hgnc": "HGNC:1461",
        "name": "calcium/calmodulin dependent protein kinase II beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/camk2b"
      },
      {
        "slug": "cdc42",
        "symbol": "CDC42",
        "hgnc": "HGNC:1736",
        "name": "cell division cycle 42",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cdc42"
      },
      {
        "slug": "cdc42bpb",
        "symbol": "CDC42BPB",
        "hgnc": "HGNC:1738",
        "name": "CDC42 binding protein kinase beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cdc42bpb"
      },
      {
        "slug": "cep295",
        "symbol": "CEP295",
        "hgnc": "HGNC:29366",
        "name": "centrosomal protein 295",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cep295"
      },
      {
        "slug": "dph1",
        "symbol": "DPH1",
        "hgnc": "HGNC:3003",
        "name": "diphthamide biosynthesis 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph1"
      },
      {
        "slug": "dph2",
        "symbol": "DPH2",
        "hgnc": "HGNC:3004",
        "name": "diphthamide biosynthesis 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dph2"
      },
      {
        "slug": "h4c5",
        "symbol": "H4C5",
        "hgnc": "HGNC:4790",
        "name": "H4 clustered histone 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/h4c5"
      },
      {
        "slug": "hk1",
        "symbol": "HK1",
        "hgnc": "HGNC:4922",
        "name": "hexokinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hk1"
      },
      {
        "slug": "katnb1",
        "symbol": "KATNB1",
        "hgnc": "HGNC:6217",
        "name": "katanin regulatory subunit B1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/katnb1"
      },
      {
        "slug": "lmbrd2",
        "symbol": "LMBRD2",
        "hgnc": "HGNC:25287",
        "name": "LMBR1 domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lmbrd2"
      },
      {
        "slug": "man2b1",
        "symbol": "MAN2B1",
        "hgnc": "HGNC:6826",
        "name": "mannosidase alpha class 2B member 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/man2b1"
      },
      {
        "slug": "mapk1",
        "symbol": "MAPK1",
        "hgnc": "HGNC:6871",
        "name": "mitogen-activated protein kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mapk1"
      },
      {
        "slug": "mecp2",
        "symbol": "MECP2",
        "hgnc": "HGNC:6990",
        "name": "methyl-CpG binding protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mecp2"
      },
      {
        "slug": "med12",
        "symbol": "MED12",
        "hgnc": "HGNC:11957",
        "name": "mediator complex subunit 12",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med12"
      },
      {
        "slug": "med13l",
        "symbol": "MED13L",
        "hgnc": "HGNC:22962",
        "name": "mediator complex subunit 13L",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med13l"
      },
      {
        "slug": "med27",
        "symbol": "MED27",
        "hgnc": "HGNC:2377",
        "name": "mediator complex subunit 27",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/med27"
      },
      {
        "slug": "naa20",
        "symbol": "NAA20",
        "hgnc": "HGNC:15908",
        "name": "N-alpha-acetyltransferase 20, NatB catalytic subunit",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/naa20"
      },
      {
        "slug": "nars1",
        "symbol": "NARS1",
        "hgnc": "HGNC:7643",
        "name": "asparaginyl-tRNA synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nars1"
      },
      {
        "slug": "ndst1",
        "symbol": "NDST1",
        "hgnc": "HGNC:7680",
        "name": "N-deacetylase and N-sulfotransferase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndst1"
      },
      {
        "slug": "pigs",
        "symbol": "PIGS",
        "hgnc": "HGNC:14937",
        "name": "phosphatidylinositol glycan anchor biosynthesis class S",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigs"
      },
      {
        "slug": "ppp1cb",
        "symbol": "PPP1CB",
        "hgnc": "HGNC:9282",
        "name": "protein phosphatase 1 catalytic subunit beta",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ppp1cb"
      },
      {
        "slug": "rhobtb2",
        "symbol": "RHOBTB2",
        "hgnc": "HGNC:18756",
        "name": "Rho related BTB domain containing 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rhobtb2"
      },
      {
        "slug": "satb1",
        "symbol": "SATB1",
        "hgnc": "HGNC:10541",
        "name": "SATB homeobox 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/satb1"
      },
      {
        "slug": "sephs1",
        "symbol": "SEPHS1",
        "hgnc": "HGNC:19685",
        "name": "selenophosphate synthetase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sephs1"
      },
      {
        "slug": "setd1a",
        "symbol": "SETD1A",
        "hgnc": "HGNC:29010",
        "name": "SET domain containing 1A, histone lysine methyltransferase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/setd1a"
      },
      {
        "slug": "shank3",
        "symbol": "SHANK3",
        "hgnc": "HGNC:14294",
        "name": "SH3 and multiple ankyrin repeat domains 3",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/shank3"
      },
      {
        "slug": "tbc1d24",
        "symbol": "TBC1D24",
        "hgnc": "HGNC:29203",
        "name": "TBC1 domain family member 24",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbc1d24"
      },
      {
        "slug": "tbx4",
        "symbol": "TBX4",
        "hgnc": "HGNC:11603",
        "name": "T-box transcription factor 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tbx4"
      },
      {
        "slug": "tti1",
        "symbol": "TTI1",
        "hgnc": "HGNC:29029",
        "name": "TELO2 interacting protein 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tti1"
      },
      {
        "slug": "twist2",
        "symbol": "TWIST2",
        "hgnc": "HGNC:20670",
        "name": "twist family bHLH transcription factor 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/twist2"
      },
      {
        "slug": "znf526",
        "symbol": "ZNF526",
        "hgnc": "HGNC:29415",
        "name": "zinc finger protein 526",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/znf526"
      },
      {
        "slug": "chd3",
        "symbol": "CHD3",
        "hgnc": "HGNC:1918",
        "name": "chromodomain helicase DNA binding protein 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chd3"
      },
      {
        "slug": "cntnap2",
        "symbol": "CNTNAP2",
        "hgnc": "HGNC:13830",
        "name": "contactin associated protein 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cntnap2"
      },
      {
        "slug": "gja5",
        "symbol": "GJA5",
        "hgnc": "HGNC:4279",
        "name": "gap junction protein alpha 5",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja5"
      },
      {
        "slug": "gja8",
        "symbol": "GJA8",
        "hgnc": "HGNC:4281",
        "name": "gap junction protein alpha 8",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gja8"
      },
      {
        "slug": "acvr1",
        "symbol": "ACVR1",
        "hgnc": "HGNC:171",
        "name": "activin A receptor type 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/acvr1"
      },
      {
        "slug": "ccdc47",
        "symbol": "CCDC47",
        "hgnc": "HGNC:24856",
        "name": "coiled-coil domain containing 47",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ccdc47"
      },
      {
        "slug": "chst3",
        "symbol": "CHST3",
        "hgnc": "HGNC:1971",
        "name": "carbohydrate sulfotransferase 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/chst3"
      },
      {
        "slug": "eif2s3",
        "symbol": "EIF2S3",
        "hgnc": "HGNC:3267",
        "name": "eukaryotic translation initiation factor 2 subunit gamma",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/eif2s3"
      },
      {
        "slug": "galns",
        "symbol": "GALNS",
        "hgnc": "HGNC:4122",
        "name": "galactosamine (N-acetyl)-6-sulfatase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/galns"
      },
      {
        "slug": "glb1",
        "symbol": "GLB1",
        "hgnc": "HGNC:4298",
        "name": "galactosidase beta 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/glb1"
      },
      {
        "slug": "ids",
        "symbol": "IDS",
        "hgnc": "HGNC:5389",
        "name": "iduronate 2-sulfatase",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ids"
      },
      {
        "slug": "ift122",
        "symbol": "IFT122",
        "hgnc": "HGNC:13556",
        "name": "intraflagellar transport 122",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ift122"
      },
      {
        "slug": "ltbp3",
        "symbol": "LTBP3",
        "hgnc": "HGNC:6716",
        "name": "latent transforming growth factor beta binding protein 3",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ltbp3"
      },
      {
        "slug": "nectin4",
        "symbol": "NECTIN4",
        "hgnc": "HGNC:19688",
        "name": "nectin cell adhesion molecule 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nectin4"
      },
      {
        "slug": "pcgf2",
        "symbol": "PCGF2",
        "hgnc": "HGNC:12929",
        "name": "polycomb group ring finger 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pcgf2"
      },
      {
        "slug": "tanc2",
        "symbol": "TANC2",
        "hgnc": "HGNC:30212",
        "name": "tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tanc2"
      },
      {
        "slug": "tp63",
        "symbol": "TP63",
        "hgnc": "HGNC:15979",
        "name": "tumor protein p63",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tp63"
      },
      {
        "slug": "zeb2",
        "symbol": "ZEB2",
        "hgnc": "HGNC:14881",
        "name": "zinc finger E-box binding homeobox 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zeb2"
      },
      {
        "slug": "zswim6",
        "symbol": "ZSWIM6",
        "hgnc": "HGNC:29316",
        "name": "zinc finger SWIM-type containing 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zswim6"
      }
    ]
  }
}