{
  "url": "https://dantelabs.com/traits/vertical-nystagmus",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "vertical-nystagmus",
    "id": "HP:0010544",
    "name": "Vertical nystagmus",
    "definition": "Vertical nystagmus may present with either up-beating or down-beating eye movements or both. When present in the straight-ahead position of gaze it is referred to as upbeat nystagmus or downbeat nystagmus.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-eye",
        "name": "Abnormality of the eye",
        "url": "https://dantelabs.com/traits/abnormality-of-the-eye"
      }
    ],
    "broader": [
      {
        "slug": "nystagmus",
        "name": "Involuntary, rapid, rhythmic eye movements",
        "url": "https://dantelabs.com/traits/nystagmus"
      }
    ],
    "narrower": [
      {
        "slug": "downbeat-nystagmus",
        "name": "Downbeat nystagmus",
        "genes": 7,
        "url": "https://dantelabs.com/traits/downbeat-nystagmus"
      },
      {
        "slug": "upbeat-nystagmus",
        "name": "Upbeat nystagmus",
        "genes": 2,
        "url": "https://dantelabs.com/traits/upbeat-nystagmus"
      }
    ],
    "genes": [
      {
        "slug": "dagla",
        "symbol": "DAGLA",
        "hgnc": "HGNC:1165",
        "name": "diacylglycerol lipase alpha",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dagla"
      },
      {
        "slug": "fastkd5",
        "symbol": "FASTKD5",
        "hgnc": "HGNC:25790",
        "name": "FASTK mitochondrial RNA regulator 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fastkd5"
      },
      {
        "slug": "inpp4a",
        "symbol": "INPP4A",
        "hgnc": "HGNC:6074",
        "name": "inositol polyphosphate-4-phosphatase type I A",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/inpp4a"
      },
      {
        "slug": "ndufs8",
        "symbol": "NDUFS8",
        "hgnc": "HGNC:7715",
        "name": "NADH:ubiquinone oxidoreductase core subunit S8",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufs8"
      },
      {
        "slug": "pigq",
        "symbol": "PIGQ",
        "hgnc": "HGNC:14135",
        "name": "phosphatidylinositol glycan anchor biosynthesis class Q",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pigq"
      },
      {
        "slug": "ttbk2",
        "symbol": "TTBK2",
        "hgnc": "HGNC:19141",
        "name": "tau tubulin kinase 2",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttbk2"
      },
      {
        "slug": "alx4",
        "symbol": "ALX4",
        "hgnc": "HGNC:450",
        "name": "ALX homeobox 4",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/alx4"
      },
      {
        "slug": "cacna1a",
        "symbol": "CACNA1A",
        "hgnc": "HGNC:1388",
        "name": "calcium voltage-gated channel subunit alpha1 A",
        "frequency": "frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/cacna1a"
      },
      {
        "slug": "echs1",
        "symbol": "ECHS1",
        "hgnc": "HGNC:3151",
        "name": "enoyl-CoA hydratase, short chain 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/echs1"
      },
      {
        "slug": "atp1a2",
        "symbol": "ATP1A2",
        "hgnc": "HGNC:800",
        "name": "ATPase Na+/K+ transporting subunit alpha 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/atp1a2"
      },
      {
        "slug": "mre11",
        "symbol": "MRE11",
        "hgnc": "HGNC:7230",
        "name": "MRE11 double strand break repair nuclease",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mre11"
      },
      {
        "slug": "pet100",
        "symbol": "PET100",
        "hgnc": "HGNC:40038",
        "name": "PET100 cytochrome c oxidase chaperone",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pet100"
      },
      {
        "slug": "pex5",
        "symbol": "PEX5",
        "hgnc": "HGNC:9719",
        "name": "peroxisomal biogenesis factor 5",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex5"
      },
      {
        "slug": "pign",
        "symbol": "PIGN",
        "hgnc": "HGNC:8967",
        "name": "phosphatidylinositol glycan anchor biosynthesis class N",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pign"
      },
      {
        "slug": "prrt2",
        "symbol": "PRRT2",
        "hgnc": "HGNC:30500",
        "name": "proline rich transmembrane protein 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prrt2"
      },
      {
        "slug": "scn1a",
        "symbol": "SCN1A",
        "hgnc": "HGNC:10585",
        "name": "sodium voltage-gated channel alpha subunit 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/scn1a"
      },
      {
        "slug": "tmem106b",
        "symbol": "TMEM106B",
        "hgnc": "HGNC:22407",
        "name": "transmembrane protein 106B",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/tmem106b"
      },
      {
        "slug": "ttr",
        "symbol": "TTR",
        "hgnc": "HGNC:12405",
        "name": "transthyretin",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ttr"
      }
    ]
  }
}