{
  "url": "https://dantelabs.com/traits/vascular-tortuosity",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "vascular-tortuosity",
    "id": "HP:0004948",
    "name": "Twisted blood vessels",
    "label": "Vascular tortuosity",
    "definition": "Abnormal twisting of arteries or veins.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-cardiovascular-system",
        "name": "Abnormality of the cardiovascular system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-cardiovascular-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormal-blood-vessel-morphology",
        "name": "Abnormal blood vessel morphology",
        "url": "https://dantelabs.com/traits/abnormal-blood-vessel-morphology"
      }
    ],
    "narrower": [
      {
        "slug": "arterial-tortuosity",
        "name": "Arterial tortuosity",
        "genes": 10,
        "url": "https://dantelabs.com/traits/arterial-tortuosity"
      }
    ],
    "genes": [
      {
        "slug": "efemp2",
        "symbol": "EFEMP2",
        "hgnc": "HGNC:3219",
        "name": "EGF-like fibulin extracellular matrix protein 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/efemp2"
      },
      {
        "slug": "rasa1",
        "symbol": "RASA1",
        "hgnc": "HGNC:9871",
        "name": "RAS p21 protein activator 1",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/rasa1"
      },
      {
        "slug": "idh1",
        "symbol": "IDH1",
        "hgnc": "HGNC:5382",
        "name": "isocitrate dehydrogenase (NADP(+)) 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/idh1"
      },
      {
        "slug": "fbln5",
        "symbol": "FBLN5",
        "hgnc": "HGNC:3602",
        "name": "fibulin 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbln5"
      }
    ]
  }
}