{
  "url": "https://dantelabs.com/traits/urethral-valve",
  "trait": {
    "bundleId": "2026.10.16-c6eea6bf",
    "release": "2026-09-01",
    "slug": "urethral-valve",
    "id": "HP:0010481",
    "name": "Urethral valve",
    "definition": "The presence of an abnormal membrane obstructing the urethra.",
    "synonyms": [],
    "systems": [
      {
        "slug": "abnormality-of-the-genitourinary-system",
        "name": "Abnormality of the genitourinary system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-genitourinary-system"
      }
    ],
    "broader": [
      {
        "slug": "urethral-obstruction",
        "name": "Urethral obstruction",
        "url": "https://dantelabs.com/traits/urethral-obstruction"
      }
    ],
    "narrower": [
      {
        "slug": "congenital-posterior-urethral-valve",
        "name": "Congenital posterior urethral valve",
        "genes": 9,
        "url": "https://dantelabs.com/traits/congenital-posterior-urethral-valve"
      }
    ],
    "genes": [
      {
        "slug": "dact1",
        "symbol": "DACT1",
        "hgnc": "HGNC:17748",
        "name": "dishevelled binding antagonist of beta catenin 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dact1"
      },
      {
        "slug": "sall1",
        "symbol": "SALL1",
        "hgnc": "HGNC:10524",
        "name": "spalt like transcription factor 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/sall1"
      },
      {
        "slug": "hpse2",
        "symbol": "HPSE2",
        "hgnc": "HGNC:18374",
        "name": "heparanase 2 (inactive)",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hpse2"
      },
      {
        "slug": "igf2",
        "symbol": "IGF2",
        "hgnc": "HGNC:5466",
        "name": "insulin like growth factor 2",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/igf2"
      }
    ]
  }
}